Chemical decay of an antibiotic inverts selection for resistance

Antibiotics are often unstable, decaying into various compounds with potential biological activities. We found that as tetracycline degrades, the competitive advantage conferred to bacteria by resistance not only diminishes, but reverses to become a prolonged disadvantage due to the activities of mo...

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Detalles Bibliográficos
Autores principales: Palmer, Adam C., Angelino, Elaine, Kishony, Roy
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811317/
https://www.ncbi.nlm.nih.gov/pubmed/20081825
http://dx.doi.org/10.1038/nchembio.289
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author Palmer, Adam C.
Angelino, Elaine
Kishony, Roy
author_facet Palmer, Adam C.
Angelino, Elaine
Kishony, Roy
author_sort Palmer, Adam C.
collection PubMed
description Antibiotics are often unstable, decaying into various compounds with potential biological activities. We found that as tetracycline degrades, the competitive advantage conferred to bacteria by resistance not only diminishes, but reverses to become a prolonged disadvantage due to the activities of more stable degradation products. Tetracycline decay can lead to net selection against resistance, which may help explain the puzzling coexistence of sensitive and resistant strains in natural environments.
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spelling pubmed-28113172010-08-01 Chemical decay of an antibiotic inverts selection for resistance Palmer, Adam C. Angelino, Elaine Kishony, Roy Nat Chem Biol Article Antibiotics are often unstable, decaying into various compounds with potential biological activities. We found that as tetracycline degrades, the competitive advantage conferred to bacteria by resistance not only diminishes, but reverses to become a prolonged disadvantage due to the activities of more stable degradation products. Tetracycline decay can lead to net selection against resistance, which may help explain the puzzling coexistence of sensitive and resistant strains in natural environments. 2010-01-10 2010-02 /pmc/articles/PMC2811317/ /pubmed/20081825 http://dx.doi.org/10.1038/nchembio.289 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Palmer, Adam C.
Angelino, Elaine
Kishony, Roy
Chemical decay of an antibiotic inverts selection for resistance
title Chemical decay of an antibiotic inverts selection for resistance
title_full Chemical decay of an antibiotic inverts selection for resistance
title_fullStr Chemical decay of an antibiotic inverts selection for resistance
title_full_unstemmed Chemical decay of an antibiotic inverts selection for resistance
title_short Chemical decay of an antibiotic inverts selection for resistance
title_sort chemical decay of an antibiotic inverts selection for resistance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811317/
https://www.ncbi.nlm.nih.gov/pubmed/20081825
http://dx.doi.org/10.1038/nchembio.289
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