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AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

In the present study we characterize the properties of the potent MCT1 (monocarboxylate transporter 1) inhibitor AR-C155858. Inhibitor titrations of L-lactate transport by MCT1 in rat erythrocytes were used to determine the K(i) value and number of AR-C155858-binding sites (Et) on MCT1 and the turno...

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Detalles Bibliográficos
Autores principales:	Ovens, Matthew J., Davies, Andrew J., Wilson, Marieangela C., Murray, Clare M., Halestrap, Andrew P.
Formato:	Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811425/ https://www.ncbi.nlm.nih.gov/pubmed/19929853 http://dx.doi.org/10.1042/BJ20091515

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