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MMP-9, a Potential Target for Cerebral Ischemic Treatment

Matrix metalloproteinase-9 (MMP-9) which is a member of matrix metalloproteinases family that normally remodel the extracellular matrix, has been shown to play an important role in both animal models of cerebral ischemia and human stroke. The expression of MMP-9 is elevated after cerebral ischemia w...

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Detalles Bibliográficos
Autores principales: Dong, Xue, Song, Yu-Ning, Liu, Wei-Guo, Guo, Xiu-Li
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811860/
https://www.ncbi.nlm.nih.gov/pubmed/20514206
http://dx.doi.org/10.2174/157015909790031157
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author Dong, Xue
Song, Yu-Ning
Liu, Wei-Guo
Guo, Xiu-Li
author_facet Dong, Xue
Song, Yu-Ning
Liu, Wei-Guo
Guo, Xiu-Li
author_sort Dong, Xue
collection PubMed
description Matrix metalloproteinase-9 (MMP-9) which is a member of matrix metalloproteinases family that normally remodel the extracellular matrix, has been shown to play an important role in both animal models of cerebral ischemia and human stroke. The expression of MMP-9 is elevated after cerebral ischemia which is involved in accelerating matrix degradation, disrupting the blood-brain barrier, increasing the infarct size and relating to hemorrhagic transformation. Recently, many drugs, such as tetracycline derivatives, cyclooxygenase inhibitors, ACEI inhibitors and AT1 receptor blockers, etc., have been found to attenuate the elevated expression levels of MMP-9 after ischemia and to reduce the damage of cerebral ischemic. This article reviews the physiological features of MMP-9 and its important role in the genesis, propagation, and therapeutics of cerebral ischemic diseases.
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spelling pubmed-28118602010-06-01 MMP-9, a Potential Target for Cerebral Ischemic Treatment Dong, Xue Song, Yu-Ning Liu, Wei-Guo Guo, Xiu-Li Curr Neuropharmacol Article Matrix metalloproteinase-9 (MMP-9) which is a member of matrix metalloproteinases family that normally remodel the extracellular matrix, has been shown to play an important role in both animal models of cerebral ischemia and human stroke. The expression of MMP-9 is elevated after cerebral ischemia which is involved in accelerating matrix degradation, disrupting the blood-brain barrier, increasing the infarct size and relating to hemorrhagic transformation. Recently, many drugs, such as tetracycline derivatives, cyclooxygenase inhibitors, ACEI inhibitors and AT1 receptor blockers, etc., have been found to attenuate the elevated expression levels of MMP-9 after ischemia and to reduce the damage of cerebral ischemic. This article reviews the physiological features of MMP-9 and its important role in the genesis, propagation, and therapeutics of cerebral ischemic diseases. Bentham Science Publishers Ltd. 2009-12 /pmc/articles/PMC2811860/ /pubmed/20514206 http://dx.doi.org/10.2174/157015909790031157 Text en ©2009 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Dong, Xue
Song, Yu-Ning
Liu, Wei-Guo
Guo, Xiu-Li
MMP-9, a Potential Target for Cerebral Ischemic Treatment
title MMP-9, a Potential Target for Cerebral Ischemic Treatment
title_full MMP-9, a Potential Target for Cerebral Ischemic Treatment
title_fullStr MMP-9, a Potential Target for Cerebral Ischemic Treatment
title_full_unstemmed MMP-9, a Potential Target for Cerebral Ischemic Treatment
title_short MMP-9, a Potential Target for Cerebral Ischemic Treatment
title_sort mmp-9, a potential target for cerebral ischemic treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811860/
https://www.ncbi.nlm.nih.gov/pubmed/20514206
http://dx.doi.org/10.2174/157015909790031157
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