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Intrinsic versus extrinsic voltage sensitivity of blocker interaction with an ion channel pore
Many physiological and synthetic agents act by occluding the ion conduction pore of ion channels. A hallmark of charged blockers is that their apparent affinity for the pore usually varies with membrane voltage. Two models have been proposed to explain this voltage sensitivity. One model assumes tha...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812505/ https://www.ncbi.nlm.nih.gov/pubmed/20100894 http://dx.doi.org/10.1085/jgp.200910324 |