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Viral adaptation to immune selection pressure by HLA class I–restricted CTL responses targeting epitopes in HIV frameshift sequences

CD8(+) cytotoxic T lymphocyte (CTL)–mediated immune responses to HIV contribute to viral control in vivo. Epitopes encoded by alternative reading frame (ARF) peptides may be targeted by CTLs as well, but their frequency and in vivo relevance are unknown. Using host genetic (human leukocyte antigen [...

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Detalles Bibliográficos
Autores principales:	Berger, Christoph T., Carlson, Jonathan M., Brumme, Chanson J., Hartman, Kari L., Brumme, Zabrina L., Henry, Leah M., Rosato, Pamela C., Piechocka-Trocha, Alicja, Brockman, Mark A., Harrigan, P. Richard, Heckerman, David, Kaufmann, Daniel E., Brander, Christian
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812535/ https://www.ncbi.nlm.nih.gov/pubmed/20065065 http://dx.doi.org/10.1084/jem.20091808

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