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The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells

The cytidine deaminase APOBEC3G (A3G) enzyme exerts an intrinsic anti–human immunodeficiency virus (HIV) defense by introducing lethal G-to-A hypermutations in the viral genome. The HIV-1 viral infectivity factor (Vif) protein triggers degradation of A3G and counteracts this antiviral effect. The im...

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Detalles Bibliográficos
Autores principales:	Casartelli, Nicoletta, Guivel-Benhassine, Florence, Bouziat, Romain, Brandler, Samantha, Schwartz, Olivier, Moris, Arnaud
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812543/ https://www.ncbi.nlm.nih.gov/pubmed/20038599 http://dx.doi.org/10.1084/jem.20091933

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