Cargando…
Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1
Multiple sclerosis and its preclinical model, experimental autoimmune encephalomyelitis, are marked by perivascular inflammation and demyelination. Myeloid cells, derived from circulating progenitors, are a prominent component of the inflammatory infiltrate and are believed to directly contribute to...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812551/ https://www.ncbi.nlm.nih.gov/pubmed/20038601 http://dx.doi.org/10.1084/jem.20091508 |
_version_ | 1782176845670645760 |
---|---|
author | Xi, Hongkang Katschke, Kenneth J. Helmy, Karim Y. Wark, Paige A. Kljavin, Noelyn Clark, Hilary Eastham-Anderson, Jeffrey Shek, Theresa Roose-Girma, Merone Ghilardi, Nico van Lookeren Campagne, Menno |
author_facet | Xi, Hongkang Katschke, Kenneth J. Helmy, Karim Y. Wark, Paige A. Kljavin, Noelyn Clark, Hilary Eastham-Anderson, Jeffrey Shek, Theresa Roose-Girma, Merone Ghilardi, Nico van Lookeren Campagne, Menno |
author_sort | Xi, Hongkang |
collection | PubMed |
description | Multiple sclerosis and its preclinical model, experimental autoimmune encephalomyelitis, are marked by perivascular inflammation and demyelination. Myeloid cells, derived from circulating progenitors, are a prominent component of the inflammatory infiltrate and are believed to directly contribute to demyelination and axonal damage. How the cytotoxic activity of these myeloid cells is regulated is poorly understood. We identify CMRF-35–like molecule-1 (CLM-1) as a negative regulator of autoimmune demyelination. CLM-1 is expressed on inflammatory myeloid cells present in demyelinating areas of the spinal cord after immunization of mice with MOG(35-55) (myelin oligodendrocyte glycoprotein) peptide. Absence of CLM-1 resulted in significantly increased nitric oxide and proinflammatory cytokine production, along with increased demyelination and worsened clinical scores, whereas T cell responses in the periphery or in the spinal cord remained unaffected. This study thus identifies CLM-1 as a negative regulator of myeloid effector cells in autoimmune demyelination. |
format | Text |
id | pubmed-2812551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-28125512010-07-18 Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1 Xi, Hongkang Katschke, Kenneth J. Helmy, Karim Y. Wark, Paige A. Kljavin, Noelyn Clark, Hilary Eastham-Anderson, Jeffrey Shek, Theresa Roose-Girma, Merone Ghilardi, Nico van Lookeren Campagne, Menno J Exp Med Brief Definitive Report Multiple sclerosis and its preclinical model, experimental autoimmune encephalomyelitis, are marked by perivascular inflammation and demyelination. Myeloid cells, derived from circulating progenitors, are a prominent component of the inflammatory infiltrate and are believed to directly contribute to demyelination and axonal damage. How the cytotoxic activity of these myeloid cells is regulated is poorly understood. We identify CMRF-35–like molecule-1 (CLM-1) as a negative regulator of autoimmune demyelination. CLM-1 is expressed on inflammatory myeloid cells present in demyelinating areas of the spinal cord after immunization of mice with MOG(35-55) (myelin oligodendrocyte glycoprotein) peptide. Absence of CLM-1 resulted in significantly increased nitric oxide and proinflammatory cytokine production, along with increased demyelination and worsened clinical scores, whereas T cell responses in the periphery or in the spinal cord remained unaffected. This study thus identifies CLM-1 as a negative regulator of myeloid effector cells in autoimmune demyelination. The Rockefeller University Press 2010-01-18 /pmc/articles/PMC2812551/ /pubmed/20038601 http://dx.doi.org/10.1084/jem.20091508 Text en © 2010 Xi et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Brief Definitive Report Xi, Hongkang Katschke, Kenneth J. Helmy, Karim Y. Wark, Paige A. Kljavin, Noelyn Clark, Hilary Eastham-Anderson, Jeffrey Shek, Theresa Roose-Girma, Merone Ghilardi, Nico van Lookeren Campagne, Menno Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1 |
title | Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1 |
title_full | Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1 |
title_fullStr | Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1 |
title_full_unstemmed | Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1 |
title_short | Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1 |
title_sort | negative regulation of autoimmune demyelination by the inhibitory receptor clm-1 |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812551/ https://www.ncbi.nlm.nih.gov/pubmed/20038601 http://dx.doi.org/10.1084/jem.20091508 |
work_keys_str_mv | AT xihongkang negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT katschkekennethj negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT helmykarimy negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT warkpaigea negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT kljavinnoelyn negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT clarkhilary negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT easthamandersonjeffrey negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT shektheresa negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT roosegirmamerone negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT ghilardinico negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 AT vanlookerencampagnemenno negativeregulationofautoimmunedemyelinationbytheinhibitoryreceptorclm1 |