Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

The anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase functions with the E2 ubiquitin–conjugating enzyme UbcH10 in the orderly progression through mitosis by marking key mitotic regulators for destruction by the 26-S proteasome. UbcH10 is overexpressed in many human cancer types and i...

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Detalles Bibliográficos
Autores principales: van Ree, Janine H., Jeganathan, Karthik B., Malureanu, Liviu, van Deursen, Jan M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812857/
https://www.ncbi.nlm.nih.gov/pubmed/20065091
http://dx.doi.org/10.1083/jcb.200906147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812857/
https://www.ncbi.nlm.nih.gov/pubmed/20065091
http://dx.doi.org/10.1083/jcb.200906147

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