Cargando…

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

The anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase functions with the E2 ubiquitin–conjugating enzyme UbcH10 in the orderly progression through mitosis by marking key mitotic regulators for destruction by the 26-S proteasome. UbcH10 is overexpressed in many human cancer types and i...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Ree, Janine H., Jeganathan, Karthik B., Malureanu, Liviu, van Deursen, Jan M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812857/ https://www.ncbi.nlm.nih.gov/pubmed/20065091 http://dx.doi.org/10.1083/jcb.200906147

Ejemplares similares

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
por: Jeganathan, Karthik, et al.
Publicado: (2007)

Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7
por: Whitcomb, Elizabeth A, et al.
Publicado: (2009)

Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c
por: Wu, Fangshu, et al.
Publicado: (2017)

Molecular Simulation Elaborating the Mechanism of 1β-Hydroxy Alantolactone Inhibiting Ubiquitin-Conjugating Enzyme UbcH5s
por: Xu, Youdong, et al.
Publicado: (2020)

Segregating out UbcH10's role in tumorigenesis
por: Short, Ben
Publicado: (2010)

UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas
por: Pallante, P, et al.
Publicado: (2005)

UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer
por: Li, Shang-Ze, et al.
Publicado: (2014)

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation
por: Babu, J. Ramesh, et al.
Publicado: (2003)

Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis
por: Qi, Simin, et al.
Publicado: (2022)

Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer
por: Fujita, Takeo, et al.
Publicado: (2009)

Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex
por: Patel, Amrita, et al.
Publicado: (2019)

Epigenetic downregulation of the ISG15–conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma
por: Zhou, Xiaoying, et al.
Publicado: (2015)

Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division
por: He, Bin, et al.
Publicado: (2019)

Arabidopsis Ubiquitin-Conjugating Enzymes UBC7, UBC13, and UBC14 Are Required in Plant Responses to Multiple Stress Conditions
por: Feng, Hui, et al.
Publicado: (2020)

UbcH10 a Major Actor in Cancerogenesis and a Potential Tool for Diagnosis and Therapy
por: Presta, Ivan, et al.
Publicado: (2020)

Arabidopsis Ubiquitin-Conjugating Enzymes UBC4, UBC5, and UBC6 Have Major Functions in Sugar Metabolism and Leaf Senescence
por: Wang, Sheng, et al.
Publicado: (2022)

UbcH7 reactivity profile reveals Parkin and HHARI to be RING/HECT hybrids
por: Wenzel, Dawn M., et al.
Publicado: (2011)

Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability
por: Hamada, Masakazu, et al.
Publicado: (2011)

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis
por: Malureanu, Liviu, et al.
Publicado: (2010)

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation
por: Condos, Tara EC, et al.
Publicado: (2018)

Knockdown of UbcH10 Enhances the Chemosensitivity of Dual Drug Resistant Breast Cancer Cells to Epirubicin and Docetaxel
por: Wang, Cheng, et al.
Publicado: (2015)

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression
por: Ricke, Robin M., et al.
Publicado: (2012)

Endomembranes promote chromosome missegregation by ensheathing misaligned chromosomes
por: Ferrandiz, Nuria, et al.
Publicado: (2022)

Overexpression of VrUBC1, a Mung Bean E2 Ubiquitin-Conjugating Enzyme, Enhances Osmotic Stress Tolerance in Arabidopsis
por: Chung, Eunsook, et al.
Publicado: (2013)

Ubiquitin-Conjugating Enzyme OsUBC11 Affects the Development of Roots via Auxin Pathway
por: Han, Yunfei, et al.
Publicado: (2023)

Ubiquitin-Conjugating Enzymes Ubc1 and Ubc4 Mediate the Turnover of Hap4, a Master Regulator of Mitochondrial Biogenesis in Saccharomyces cerevisiae
por: Capps, Denise, et al.
Publicado: (2022)

Chromosome Missegregation Associated with RUVBL1 Deficiency
por: Gentili, Christian, et al.
Publicado: (2015)

UBC13 is an RNF213‐associated E2 ubiquitin‐conjugating enzyme, and Lysine 63‐linked ubiquitination by the RNF213‐UBC13 axis is responsible for angiogenic activity
por: Habu, Toshiyuki, et al.
Publicado: (2021)

Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice
por: Baker, Darren J., et al.
Publicado: (2006)

Cdc20 Is Critical for Meiosis I and Fertility of Female Mice
por: Jin, Fang, et al.
Publicado: (2010)

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation
por: Wijshake, Tobias, et al.
Publicado: (2012)

Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin
por: Correale, Stefania, et al.
Publicado: (2014)

Reprogramming to Pluripotency Can Conceal Somatic Cell Chromosomal Instability
por: Hamada, Masakazu, et al.
Publicado: (2012)

Rice ubiquitin‐conjugating enzyme OsUBC26 is essential for immunity to the blast fungus Magnaporthe oryzae
por: Liu, Xin, et al.
Publicado: (2021)

Arabidopsis ubiquitin-conjugating enzyme UBC22 is required for female gametophyte development and likely involved in Lys11-linked ubiquitination
por: Wang, Sheng, et al.
Publicado: (2016)

The Ubiquitin Conjugating Enzyme UbcD1 is Required for Notch Signaling Activation During Drosophila Wing Development
por: Zhang, Fengchao, et al.
Publicado: (2021)

Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes
por: Topper, Leana M., et al.
Publicado: (2001)

KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint
por: Lei, Han, et al.
Publicado: (2020)

Substrate stiffness effect and chromosome missegregation in hIPS cells
por: Acevedo-Acevedo, Suehelay, et al.
Publicado: (2015)

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1
por: Dove, Katja K., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_v4ceiiql29hbdv4i3gr5psh59e