Cargando…

In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells

The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied viral dynamics during antiretroviral treatment of simian immunodeficiency virus (SIV) infected rhesus macaques follo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wong, Joseph K., Strain, Matthew C., Porrata, Rodin, Reay, Elizabeth, Sankaran-Walters, Sumathi, Ignacio, Caroline C., Russell, Theresa, Pillai, Satish K., Looney, David J., Dandekar, Satya
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813272/ https://www.ncbi.nlm.nih.gov/pubmed/20126442 http://dx.doi.org/10.1371/journal.ppat.1000748

Ejemplares similares

Divergent Annexin A1 expression in periphery and gut is associated with systemic immune activation and impaired gut immune response during SIV infection
por: Sena, Angela A. S., et al.
Publicado: (2016)

Transcription Profiling Reveals Potential Mechanisms of Dysbiosis in the Oral Microbiome of Rhesus Macaques with Chronic Untreated SIV Infection
por: Ocon, Susan, et al.
Publicado: (2013)

Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection
por: Glavan, Tiffany W., et al.
Publicado: (2015)

CTL Escape and Viral Fitness in HIV/SIV Infection
por: Seki, Sayuri, et al.
Publicado: (2012)

Early Mucosal Sensing of SIV Infection by Paneth Cells Induces IL-1β Production and Initiates Gut Epithelial Disruption
por: Hirao, Lauren A., et al.
Publicado: (2014)

Characterization of an Effective CTL Response against HIV and SIV Infections
por: Genescà, Meritxell
Publicado: (2011)

PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host–microbe intersection during SIV infection
por: Crakes, Katti R., et al.
Publicado: (2019)

Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection
por: Ganusov, Vitaly V, et al.
Publicado: (2006)

Virus and CTL dynamics in the extrafollicular and follicular tissue compartments in SIV-infected macaques
por: Wodarz, Dominik, et al.
Publicado: (2018)

Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus Monkeys
por: Whitney, James B., et al.
Publicado: (2014)

Quantification of the Relative Importance of CTL, B Cell, NK Cell, and Target Cell Limitation in the Control of Primary SIV-Infection
por: Elemans, Marjet, et al.
Publicado: (2011)

Immune clearance of highly pathogenic SIV infection
por: Hansen, Scott G., et al.
Publicado: (2013)

Control of Viremia and Prevention of AIDS following Immunotherapy of SIV-Infected Macaques with Peptide-Pulsed Blood
por: De Rose, Robert, et al.
Publicado: (2008)

Gut germinal center regeneration and enhanced antiviral immunity by mesenchymal stem/stromal cells in SIV infection
por: Weber, Mariana G., et al.
Publicado: (2021)

Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control
por: Caetano, Diogo Gama, et al.
Publicado: (2018)

Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques
por: Blasi, Maria, et al.
Publicado: (2020)

Preservation of a subset of SIV-specific central memory CD4+ T cells correlates with control of viremia in SIVmac251 infected macaques
por: Felber, Barbara K, et al.
Publicado: (2006)

Limited Impact of Passive Non-Neutralizing Antibody Immunization in Acute SIV Infection on Viremia Control in Rhesus Macaques
por: Nakane, Taku, et al.
Publicado: (2013)

Evidence of an increased pathogenic footprint in the lingual microbiome of untreated HIV infected patients
por: Dang, Angeline T, et al.
Publicado: (2012)

Gene expression of Lactobacillus plantarum and the commensal microbiota in the ileum of healthy and early SIV-infected rhesus macaques
por: Golomb, Benjamin L., et al.
Publicado: (2016)

Biologically-Directed Modeling Reflects Cytolytic Clearance of SIV-Infected Cells In Vivo in Macaques
por: Wick, W. David, et al.
Publicado: (2012)

Chronic HIV Infection Enhances the Responsiveness of Antigen Presenting Cells to Commensal Lactobacillus
por: Nagy, Lauren H., et al.
Publicado: (2013)

A Tonsillar PolyICLC/AT-2 SIV Therapeutic Vaccine Maintains Low Viremia Following Antiretroviral Therapy Cessation
por: Vagenas, Panagiotis, et al.
Publicado: (2010)

Viral CTL Escape Mutants Are Generated in Lymph Nodes and Subsequently Become Fixed in Plasma and Rectal Mucosa during Acute SIV Infection of Macaques
por: Vanderford, Thomas H., et al.
Publicado: (2011)

Altered Expression of ACE2 and Co-receptors of SARS-CoV-2 in the Gut Mucosa of the SIV Model of HIV/AIDS
por: Hu, Shuang, et al.
Publicado: (2022)

Dysregulation of Anti-Inflammatory Annexin A1 Expression in Progressive Crohns Disease
por: Sena, Angela, et al.
Publicado: (2013)

Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response
por: Meyer, Manuela F, et al.
Publicado: (2007)

Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment
por: Bissel, Stephanie J., et al.
Publicado: (2018)

A peptide-loaded dendritic cell based cytotoxic T-lymphocyte (CTL) vaccination strategy using peptides that span SIV Tat, Rev, and Env overlapping reading frames
por: Klase, Zachary, et al.
Publicado: (2006)

Sex differences matter in the gut: effect on mucosal immune activation and inflammation
por: Sankaran-Walters, Sumathi, et al.
Publicado: (2013)

Guardians of the Gut: Enteric Defensins
por: Sankaran-Walters, Sumathi, et al.
Publicado: (2017)

Loss and regain of SIV control upon CD8+ cell depletion in vivo in SIV-controller macaques is not associated with efficient SIV specific CD8+ T-cells
por: Hamimi, C, et al.
Publicado: (2012)

Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection
por: Li, Shengbin, et al.
Publicado: (2019)

SIV replication in human cells
por: Sakuma, Ryuta, et al.
Publicado: (2012)

Cells producing residual viremia during antiretroviral treatment appear to contribute to rebound viremia following interruption of treatment
por: Aamer, Hadega A., et al.
Publicado: (2020)

Gargling with 7.5% Sodium Bicarbonate Solution for SARS-CoV-2 Viremia Clearance: Our Institutional Clinical Experience
por: Kumar, Neeraj, et al.
Publicado: (2021)

Protection against highly pathogenic SIV by BCG-SIV recombinant priming and attenuated replicating vaccinia-SIV recombinant boosting
por: Zhang, X, et al.
Publicado: (2012)

Bocavirus viremia
por: Sukkaromdee, Pathoom, et al.
Publicado: (2015)

Broad CTL Response in Early HIV Infection Drives Multiple Concurrent CTL Escapes
por: Leviyang, Sivan, et al.
Publicado: (2015)

P11-19. Altered mucosal distribution of SIV-specific T cells in Rhesus macaques infected with the live-attenuated Rev-independent SIV
por: Valentin, A, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_5odfhjtt6nc749i9jq56tr76ni