Cargando…

Echinocandin Treatment of Pneumocystis Pneumonia in Rodent Models Depletes Cysts Leaving Trophic Burdens That Cannot Transmit the Infection

Fungi in the genus Pneumocystis cause pneumonia (PCP) in hosts with debilitated immune systems and are emerging as co-morbidity factors associated with chronic diseases such as COPD. Limited therapeutic choices and poor understanding of the life cycle are a result of the inability of these fungi to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cushion, Melanie T., Linke, Michael J., Ashbaugh, Alan, Sesterhenn, Tom, Collins, Margaret S., Lynch, Keeley, Brubaker, Ronald, Walzer, Peter D.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813285/ https://www.ncbi.nlm.nih.gov/pubmed/20126455 http://dx.doi.org/10.1371/journal.pone.0008524

Ejemplares similares

The Long-Acting Echinocandin, Rezafungin, Prevents Pneumocystis Pneumonia and Eliminates Pneumocystis from the Lungs in Prophylaxis and Murine Treatment Models
por: Cushion, Melanie T., et al.
Publicado: (2021)

The Effects of Sex and Strain on Pneumocystis murina Fungal Burdens in Mice
por: Macioce-Tisdale, Nikeya L., et al.
Publicado: (2022)

Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation
por: Cushion, Melanie T., et al.
Publicado: (2018)

Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure
por: Linke, Michael J, et al.
Publicado: (2009)

Functional Characterization of Pneumocystis carinii Inositol Transporter 1
por: Cushion, Melanie T., et al.
Publicado: (2016)

Efficacy of Rezafungin in Prophylactic Mouse Models of Invasive Candidiasis, Aspergillosis, and Pneumocystis Pneumonia
por: Miesel, Lynn, et al.
Publicado: (2021)

1251. Prevention of Pneumocystis Pneumonia by Ibrexafungerp in a Murine Prophylaxis Model
por: Borroto-Esoda, Katyna, et al.
Publicado: (2020)

Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
por: Linke, Michael J., et al.
Publicado: (2003)

A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice
por: Liu, Guan-Sheng, et al.
Publicado: (2018)

Comparative Genomics of Pneumocystis Species Suggests the Absence of Genes for myo-Inositol Synthesis and Reliance on Inositol Transport and Metabolism
por: Porollo, Aleksey, et al.
Publicado: (2014)

The Promise of Lung Organoids for Growth and Investigation of Pneumocystis Species
por: Tisdale-Macioce, Nikeya, et al.
Publicado: (2021)

Correction to: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice
por: Liu, Guan-Sheng, et al.
Publicado: (2019)

Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication
por: Cushion, Melanie T., et al.
Publicado: (2022)

Expression and Immunostaining Analyses Suggest that Pneumocystis Primary Homothallism Involves Trophic Cells Displaying Both Plus and Minus Pheromone Receptors
por: Luraschi, A., et al.
Publicado: (2019)

Transcriptome of Pneumocystis carinii during Fulminate Infection: Carbohydrate Metabolism and the Concept of a Compatible Parasite
por: Cushion, Melanie T., et al.
Publicado: (2007)

Is sex necessary for the proliferation and transmission of Pneumocystis?
por: Hauser, Philippe M., et al.
Publicado: (2018)

Ploidy of Cell-Sorted Trophic and Cystic Forms of Pneumocystis carinii
por: Martinez, Anna, et al.
Publicado: (2011)

A Pilot Study of Echinocandin Combination with Trimethoprim/Sulfamethoxazole and Clindamycin for the Treatment of AIDS Patients with Pneumocystis Pneumonia
por: Wang, Mengyan, et al.
Publicado: (2019)

Assembly and Annotation of Pneumocystis jirovecii from the Human Lung Microbiome
por: Cushion, Melanie T., et al.
Publicado: (2013)

Are Members of the Fungal Genus Pneumocystis (a) Commensals; (b) Opportunists; (c) Pathogens; or (d) All of the Above?
por: Cushion, Melanie T.
Publicado: (2010)

Efficacy of Trimethoprim–Sulfamethoxazole in Combination with an Echinocandin as a First-Line Treatment Option for Pneumocystis Pneumonia: A Systematic Review and Meta-Analysis
por: Kato, Hideo, et al.
Publicado: (2022)

Comparison of echinocandin antifungals
por: Eschenauer, Gregory, et al.
Publicado: (2007)

Fungal echinocandin resistance
por: Walker, Louise A., et al.
Publicado: (2010)

Fungal echinocandin resistance
por: Munro, Carol A
Publicado: (2010)

Fish mitigate trophic depletion in marine cave ecosystems
por: Bussotti, Simona, et al.
Publicado: (2018)

Humoral Immune Responses to Pneumocystis jirovecii Antigens in HIV-Infected and Uninfected Young Children with Pneumocystis Pneumonia
por: Djawe, Kpandja, et al.
Publicado: (2013)

The Persistent Challenge of Pneumocystis Growth Outside the Mammalian Lung: Past and Future Approaches
por: Cushion, Melanie T., et al.
Publicado: (2021)

Antibody Response to Pneumocystis jirovecii: Antibody Response to Pneumocystis jirovecii Major Surface Glycoprotein
por: Daly, Kieran R., et al.
Publicado: (2006)

Trophic Niche Differentiation in Rodents and Marsupials Revealed by Stable Isotopes
por: Galetti, Mauro, et al.
Publicado: (2016)

“Illuminating” Echinocandins’ Mechanism of Action
por: Loh, Boon Shing, et al.
Publicado: (2020)

Current Epidemiology of Pneumocystis Pneumonia
por: Morris, Alison, et al.
Publicado: (2004)

What are the evolutionary constraints on larval growth in a trophically transmitted parasite?
por: Benesh, Daniel P.
Publicado: (2009)

Enzyme-Linked Immunosorbent Assay and Serologic Responses to Pneumocystis jiroveci
por: Daly, Kieran R., et al.
Publicado: (2004)

The in vitro Activity of Echinocandins Against Clinical Trichophyton rubrum Isolates and Review of the Susceptibility of T. rubrum to Echinocandins Worldwide
por: Su, Huilin, et al.
Publicado: (2023)

Recent Insights into the Paradoxical Effect of Echinocandins
por: Wagener, Johannes, et al.
Publicado: (2017)

Review on Current Status of Echinocandins Use
por: Mroczyńska, Martyna, et al.
Publicado: (2020)

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China
por: Ning, Yating, et al.
Publicado: (2022)

Sexually-Transmitted/Founder HIV-1 Cannot Be Directly Predicted from Plasma or PBMC-Derived Viral Quasispecies in the Transmitting Partner
por: Frange, Pierre, et al.
Publicado: (2013)

Correction: Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity
por: Maciejewska, D., et al.
Publicado: (2017)

Therapeutic Potential of Caspofungin Combined with Trimethoprim-Sulfamethoxazole for Pneumocystis Pneumonia: A Pilot Study in Mice
por: Lobo, Maria Luísa, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ji7nldccp3csm9sag96k4tqs71