UVB induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes

Ultraviolet (UV) radiation in sunlight is the major environmental cause of skin cancer. PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a proven critical tumor suppressor. We report here that UVB down-regulates PTEN in primary human keratinocytes, human HaCaT keratinocytes, and mou...

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Detalles Bibliográficos
Autores principales: Ming, Mei, Han, Weinong, Maddox, Jessica, Soltani, Keyoumars, Shea, Christopher R., Freeman, Diane M., He, Yu-Ying
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813408/
https://www.ncbi.nlm.nih.gov/pubmed/19881543
http://dx.doi.org/10.1038/onc.2009.357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813408/
https://www.ncbi.nlm.nih.gov/pubmed/19881543
http://dx.doi.org/10.1038/onc.2009.357

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