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Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability
Accurate control of the number of centrosomes, the major microtubule-organizing centers of animal cells, is critical for the maintenance of genome integrity. Abnormalities in centrosome number can promote errors in spindle formation that lead to subsequent chromosome missegregation, and extra centro...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813471/ https://www.ncbi.nlm.nih.gov/pubmed/20100909 http://dx.doi.org/10.1083/jcb.200911102 |