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Extra-articular manifestations of rheumatoid arthritis: a hospital-based study
BACKGROUND AND OBJECTIVE: The frequency of extra-articular manifestations in rheumatoid arthritis (ExRA) differs from one country to another, so we investigated ExRA frequency in a well-defined hospital patient population with rheumatoid arthritis (RA) in Saudi Arabia. We also examined possible pred...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813651/ https://www.ncbi.nlm.nih.gov/pubmed/19448378 http://dx.doi.org/10.4103/0256-4947.51774 |
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author | Al-Ghamdi, Aisha Attar, Suzan M. |
author_facet | Al-Ghamdi, Aisha Attar, Suzan M. |
author_sort | Al-Ghamdi, Aisha |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: The frequency of extra-articular manifestations in rheumatoid arthritis (ExRA) differs from one country to another, so we investigated ExRA frequency in a well-defined hospital patient population with rheumatoid arthritis (RA) in Saudi Arabia. We also examined possible predictors of the development ExRA. METHODS: A retrospective analysis was conducted of all patients diagnosed with RA at a university hospital during a 4-year period. Cases were classified according to the 1987 American College of Rheumatology criteria for RA, and the frequency of ExRA was recorded. RESULTS: Of 140 patients who fulfilled the criteria for the diagnosis of RA, 98 (70%) developed ExRA features. Anemia occurred in 61%, thrombocytosis in 16%, pulmonary involvement in 10%, and renal amyloidosis, vasculitis and Felty syndrome were present in 6%, 2% and 1%, respectively. The mortality rate was high (16%) in patients with ExRA. The predictors for mortality were lung involvement, age over 50 years and kidney amyloidosis. CONCLUSION: ExRA were present in a substantial proportion of our patients, which lead to a worse disease outcome. Anemia, thrombocytosis and respiratory system involvement were the commonest. Early recognition and treatment are important to decrease mortality. |
format | Text |
id | pubmed-2813651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28136512010-02-08 Extra-articular manifestations of rheumatoid arthritis: a hospital-based study Al-Ghamdi, Aisha Attar, Suzan M. Ann Saudi Med Original Article BACKGROUND AND OBJECTIVE: The frequency of extra-articular manifestations in rheumatoid arthritis (ExRA) differs from one country to another, so we investigated ExRA frequency in a well-defined hospital patient population with rheumatoid arthritis (RA) in Saudi Arabia. We also examined possible predictors of the development ExRA. METHODS: A retrospective analysis was conducted of all patients diagnosed with RA at a university hospital during a 4-year period. Cases were classified according to the 1987 American College of Rheumatology criteria for RA, and the frequency of ExRA was recorded. RESULTS: Of 140 patients who fulfilled the criteria for the diagnosis of RA, 98 (70%) developed ExRA features. Anemia occurred in 61%, thrombocytosis in 16%, pulmonary involvement in 10%, and renal amyloidosis, vasculitis and Felty syndrome were present in 6%, 2% and 1%, respectively. The mortality rate was high (16%) in patients with ExRA. The predictors for mortality were lung involvement, age over 50 years and kidney amyloidosis. CONCLUSION: ExRA were present in a substantial proportion of our patients, which lead to a worse disease outcome. Anemia, thrombocytosis and respiratory system involvement were the commonest. Early recognition and treatment are important to decrease mortality. Medknow Publications 2009 /pmc/articles/PMC2813651/ /pubmed/19448378 http://dx.doi.org/10.4103/0256-4947.51774 Text en © Annals of Saudi Medicine http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Al-Ghamdi, Aisha Attar, Suzan M. Extra-articular manifestations of rheumatoid arthritis: a hospital-based study |
title | Extra-articular manifestations of rheumatoid arthritis: a hospital-based study |
title_full | Extra-articular manifestations of rheumatoid arthritis: a hospital-based study |
title_fullStr | Extra-articular manifestations of rheumatoid arthritis: a hospital-based study |
title_full_unstemmed | Extra-articular manifestations of rheumatoid arthritis: a hospital-based study |
title_short | Extra-articular manifestations of rheumatoid arthritis: a hospital-based study |
title_sort | extra-articular manifestations of rheumatoid arthritis: a hospital-based study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813651/ https://www.ncbi.nlm.nih.gov/pubmed/19448378 http://dx.doi.org/10.4103/0256-4947.51774 |
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