Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients

BACKGROUND: Our aim was to investigate the prognostic and predictive value of the oncogenic MAPKK-like protein T-cell-originated protein kinase (TOPK) stratified by KRAS and BRAF mutations in patients with sporadic, hereditary and metastatic colorectal cancer (CRC) treated with anti-EGFR therapy. ME...

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Detalles Bibliográficos
Autores principales: Zlobec, I, Molinari, F, Kovac, M, Bihl, M P, Altermatt, H J, Diebold, J, Frick, H, Germer, M, Horcic, M, Montani, M, Singer, G, Yurtsever, H, Zettl, A, Terracciano, L, Mazzucchelli, L, Saletti, P, Frattini, M, Heinimann, K, Lugli, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813744/
https://www.ncbi.nlm.nih.gov/pubmed/19935791
http://dx.doi.org/10.1038/sj.bjc.6605452

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