Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix

BACKGROUND: There is a need for simple imaging parameters capable of predicting therapeutic outcome. METHODS: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. Th...

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Autores principales: Donaldson, S B, Buckley, D L, O'Connor, J P, Davidson, S E, Carrington, B M, Jones, A P, West, C M L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813759/
https://www.ncbi.nlm.nih.gov/pubmed/19920831
http://dx.doi.org/10.1038/sj.bjc.6605415
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author Donaldson, S B
Buckley, D L
O'Connor, J P
Davidson, S E
Carrington, B M
Jones, A P
West, C M L
author_facet Donaldson, S B
Buckley, D L
O'Connor, J P
Davidson, S E
Carrington, B M
Jones, A P
West, C M L
author_sort Donaldson, S B
collection PubMed
description BACKGROUND: There is a need for simple imaging parameters capable of predicting therapeutic outcome. METHODS: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E(F)) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS). RESULTS: Tumours with high E(F) had a significantly poorer probability of DFS than those with low E(F) (P=0.011). INTERPRETATION: E(F) is a simple imaging biomarker that should be studied further in a multi-centre setting.
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spelling pubmed-28137592011-01-05 Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix Donaldson, S B Buckley, D L O'Connor, J P Davidson, S E Carrington, B M Jones, A P West, C M L Br J Cancer Short Communication BACKGROUND: There is a need for simple imaging parameters capable of predicting therapeutic outcome. METHODS: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E(F)) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS). RESULTS: Tumours with high E(F) had a significantly poorer probability of DFS than those with low E(F) (P=0.011). INTERPRETATION: E(F) is a simple imaging biomarker that should be studied further in a multi-centre setting. Nature Publishing Group 2010-01-05 2009-11-17 /pmc/articles/PMC2813759/ /pubmed/19920831 http://dx.doi.org/10.1038/sj.bjc.6605415 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Donaldson, S B
Buckley, D L
O'Connor, J P
Davidson, S E
Carrington, B M
Jones, A P
West, C M L
Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix
title Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix
title_full Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix
title_fullStr Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix
title_full_unstemmed Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix
title_short Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix
title_sort enhancing fraction measured using dynamic contrast-enhanced mri predicts disease-free survival in patients with carcinoma of the cervix
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813759/
https://www.ncbi.nlm.nih.gov/pubmed/19920831
http://dx.doi.org/10.1038/sj.bjc.6605415
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