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Self vs. non-self discrimination during CRISPR RNA-directed immunity

All immune systems must distinguish self from non-self to repel invaders without inducing autoimmunity. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci protect bacteria and archaea from invasion by phage and plasmid DNA through a genetic interference pathway1–9. CRISPR loci...

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Detalles Bibliográficos
Autores principales:	Marraffini, Luciano A., Sontheimer, Erik J.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813891/ https://www.ncbi.nlm.nih.gov/pubmed/20072129 http://dx.doi.org/10.1038/nature08703

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