Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca(2+) Channels from Secretory Granules

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Long-term (72 hr) exposure of pancreatic islets to palmitate inhibited glucose-induced insulin secretion by >50% with first- and second-phase secretion being equally suppressed. This inhibition correlated with the selective impairment of exocytosis evoked by brief (action potential-like) depolari...

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Detalles Bibliográficos
Autores principales: Hoppa, Michael B., Collins, Stephan, Ramracheya, Reshma, Hodson, Leanne, Amisten, Stefan, Zhang, Quan, Johnson, Paul, Ashcroft, Frances M., Rorsman, Patrik
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814048/
https://www.ncbi.nlm.nih.gov/pubmed/19945403
http://dx.doi.org/10.1016/j.cmet.2009.09.011
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