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DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells

Within 2–3 months of in vitro culture-expansion, mesenchymal stromal cells (MSC) undergo replicative senescence characterized by cell enlargement, loss of differentiation potential and ultimate growth arrest. In this study, we have analyzed DNA methylation changes upon long-term culture of MSC by us...

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Detalles Bibliográficos
Autores principales:	Bork, Simone, Pfister, Stefan, Witt, Hendrik, Horn, Patrick, Korn, Bernhard, Ho, Anthony D, Wagner, Wolfgang
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2010
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814091/ https://www.ncbi.nlm.nih.gov/pubmed/19895632 http://dx.doi.org/10.1111/j.1474-9726.2009.00535.x

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