Preparation, Characterization, and Analytical Application of Ramipril Membrane-Based Ion-Selective Electrode

The fabrication and electrochemical evaluation of two PVC membrane-based Ion-Selective electrodes responsive for ramipril drug have been proposed. The sensitive membranes were prepared using ramipril-phosphomolibdate and ramipril-tetraphenylborate ion-pair complexes as electroactive sensing materials in plasticized PVC support. The electrodes based on these materials provide near-Nernestian response (sensitivity of 53 ± 0.5–54 ± 0.5 mV/concentration decade) covering the concentration range of 1.0 × 10(−2)–1.0 × 10(−5) mol L(−1) with a detection limit of 3.0 × 10(−6)–4.0 × 10(−6) mol L(−1). The suggested electrodes have been successfully used in the determination of ramipril drug in some pharmaceutical formulations using direct potentiometry with average recovery of >96% and mean standard deviation of <3% (n = 5).