A Cdc42 Activation Cycle Coordinated by PI 3-Kinase during Fc Receptor-mediated Phagocytosis

Fcγ Receptor (FcR)-mediated phagocytosis by macrophages requires phosphatidylinositol 3-kinase (PI3K) and activation of the Rho-family GTPases Cdc42 and Rac1. Cdc42 is activated at the advancing edge of the phagocytic cup, where actin is concentrated, and is deactivated at the base of the cup. The t...

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Detalles Bibliográficos
Autores principales: Beemiller, Peter, Zhang, Youxin, Mohan, Suresh, Levinsohn, Erik, Gaeta, Isabella, Hoppe, Adam D., Swanson, Joel A.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814791/
https://www.ncbi.nlm.nih.gov/pubmed/19955216
http://dx.doi.org/10.1091/mbc.E08-05-0494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814791/
https://www.ncbi.nlm.nih.gov/pubmed/19955216
http://dx.doi.org/10.1091/mbc.E08-05-0494

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