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The Wilms' Tumor Suppressor Protein WT1 Is Processed by the Serine Protease HtrA2/Omi

The Wilms' tumor suppressor protein WT1 functions as a transcriptional regulator of genes controlling growth, apoptosis, and differentiation. It has become clear that WT1 can act as an oncogene in many tumors, primarily through the inhibition of apoptosis. Here, we identify the serine protease...

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Detalles Bibliográficos
Autores principales: Hartkamp, Jörg, Carpenter, Brian, Roberts, Stefan G.E.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815029/
https://www.ncbi.nlm.nih.gov/pubmed/20122399
http://dx.doi.org/10.1016/j.molcel.2009.12.023