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Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan

Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechani...

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Detalles Bibliográficos
Autores principales: Suo, Satoshi, Culotti, Joseph G., Tol, Hubert H.M. Van
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815730/
https://www.ncbi.nlm.nih.gov/pubmed/20157560
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author Suo, Satoshi
Culotti, Joseph G.
Tol, Hubert H.M. Van
author_facet Suo, Satoshi
Culotti, Joseph G.
Tol, Hubert H.M. Van
author_sort Suo, Satoshi
collection PubMed
description Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food deprivation-mediated lifespan extension. We have shown recently that dopamine signaling, activated by the tactile perception of food, suppresses octopamine signaling and that the cessation of dopamine signaling in the absence of food leads to activation of octopamine signaling. Here, we discuss the apparent conservation of neural and molecular mechanisms for dopamine regulation of octopamine/noradrenaline signaling and a possible role for dopamine in lifespan regulation.
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spelling pubmed-28157302010-02-12 Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan Suo, Satoshi Culotti, Joseph G. Tol, Hubert H.M. Van Aging (Albany NY) Research Perspective Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food deprivation-mediated lifespan extension. We have shown recently that dopamine signaling, activated by the tactile perception of food, suppresses octopamine signaling and that the cessation of dopamine signaling in the absence of food leads to activation of octopamine signaling. Here, we discuss the apparent conservation of neural and molecular mechanisms for dopamine regulation of octopamine/noradrenaline signaling and a possible role for dopamine in lifespan regulation. Impact Journals LLC 2009-10-21 /pmc/articles/PMC2815730/ /pubmed/20157560 Text en Copyright: ©2009 Suo et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Perspective
Suo, Satoshi
Culotti, Joseph G.
Tol, Hubert H.M. Van
Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan
title Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan
title_full Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan
title_fullStr Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan
title_full_unstemmed Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan
title_short Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan
title_sort dopamine suppresses octopamine signaling in c. elegans: possible involvement of dopamine in the regulation of lifespan
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815730/
https://www.ncbi.nlm.nih.gov/pubmed/20157560
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