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Paradoxical down-regulation of p16(INK4a) mRNA with advancing age in Acute Myeloid Leukemia
Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence. An important effector of aging is the cyclindependent kinase inhibitor p16(INK4a), which is al...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815746/ https://www.ncbi.nlm.nih.gov/pubmed/20157576 |