Cargando…
Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study
Rifaximin has been reported to be effective for the treatment of hepatic encephalopathy (HE) in Europe. However, it is unknown whether Rifaximin is effective for the treatment of HE in Koreans, therefore we conducted a open-label prospective randomized study to evaluate the efficacy of rifaximin ver...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815818/ https://www.ncbi.nlm.nih.gov/pubmed/15988813 http://dx.doi.org/10.3349/ymj.2005.46.3.399 |
_version_ | 1782177053708124160 |
---|---|
author | Paik, Yong-Han Lee, Kwan Sik Han, Kwang-Hyub Song, Kun Hoon Kim, Myoung Hwan Moon, Byung Soo Ahn, Sang Hoon Lee, Se Joon Park, Hyo Jin Lee, Dong Ki Chon, Chae Yoon Lee, Sang In Moon, Young Myoung |
author_facet | Paik, Yong-Han Lee, Kwan Sik Han, Kwang-Hyub Song, Kun Hoon Kim, Myoung Hwan Moon, Byung Soo Ahn, Sang Hoon Lee, Se Joon Park, Hyo Jin Lee, Dong Ki Chon, Chae Yoon Lee, Sang In Moon, Young Myoung |
author_sort | Paik, Yong-Han |
collection | PubMed |
description | Rifaximin has been reported to be effective for the treatment of hepatic encephalopathy (HE) in Europe. However, it is unknown whether Rifaximin is effective for the treatment of HE in Koreans, therefore we conducted a open-label prospective randomized study to evaluate the efficacy of rifaximin versus lactulose in Korean patients. Fifty-four patients with liver cirrhosis and hepatic encephalopathy were enrolled. Thirty-two patients were randomized to receive rifaximin and 22 to receive lactulose both over a 7-day periods. Before and at the end of treatment, gradation of blood ammonia, flapping tremor, mental status, number connection test (NCT) were performed and estimation of HE indexes determined. Both rifaximin and lactulose were effective in the majority of patients (84.4% and 95.4%, respectively, p=0.315). Blood NH3, flapping tremor, mental status, and NCT was significantly improved by rifaximin and lactulose, and the posttreatment levels of these measures were similar for the rifaximin and lactulose-treated groups, as was the HE index (rifaximin group (10.0→4.2, p=0.000); lactulose group (11.3→5.0, p=0.000)). One patient treated with rifaximin complained of abdominal pain, which was easily controlled. There was no episode of renal function impairment in either treatment group. Rifaximin proved to be as safe and as effective as lactulose for the treatment of Korean patients with hepatic encephalopathy. |
format | Text |
id | pubmed-2815818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-28158182010-02-04 Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study Paik, Yong-Han Lee, Kwan Sik Han, Kwang-Hyub Song, Kun Hoon Kim, Myoung Hwan Moon, Byung Soo Ahn, Sang Hoon Lee, Se Joon Park, Hyo Jin Lee, Dong Ki Chon, Chae Yoon Lee, Sang In Moon, Young Myoung Yonsei Med J Original Article Rifaximin has been reported to be effective for the treatment of hepatic encephalopathy (HE) in Europe. However, it is unknown whether Rifaximin is effective for the treatment of HE in Koreans, therefore we conducted a open-label prospective randomized study to evaluate the efficacy of rifaximin versus lactulose in Korean patients. Fifty-four patients with liver cirrhosis and hepatic encephalopathy were enrolled. Thirty-two patients were randomized to receive rifaximin and 22 to receive lactulose both over a 7-day periods. Before and at the end of treatment, gradation of blood ammonia, flapping tremor, mental status, number connection test (NCT) were performed and estimation of HE indexes determined. Both rifaximin and lactulose were effective in the majority of patients (84.4% and 95.4%, respectively, p=0.315). Blood NH3, flapping tremor, mental status, and NCT was significantly improved by rifaximin and lactulose, and the posttreatment levels of these measures were similar for the rifaximin and lactulose-treated groups, as was the HE index (rifaximin group (10.0→4.2, p=0.000); lactulose group (11.3→5.0, p=0.000)). One patient treated with rifaximin complained of abdominal pain, which was easily controlled. There was no episode of renal function impairment in either treatment group. Rifaximin proved to be as safe and as effective as lactulose for the treatment of Korean patients with hepatic encephalopathy. Yonsei University College of Medicine 2005-06-30 2005-06-30 /pmc/articles/PMC2815818/ /pubmed/15988813 http://dx.doi.org/10.3349/ymj.2005.46.3.399 Text en Copyright © 2005 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Paik, Yong-Han Lee, Kwan Sik Han, Kwang-Hyub Song, Kun Hoon Kim, Myoung Hwan Moon, Byung Soo Ahn, Sang Hoon Lee, Se Joon Park, Hyo Jin Lee, Dong Ki Chon, Chae Yoon Lee, Sang In Moon, Young Myoung Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study |
title | Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study |
title_full | Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study |
title_fullStr | Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study |
title_full_unstemmed | Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study |
title_short | Comparison of Rifaximin and Lactulose for the Treatment of Hepatic Encephalopathy: A Prospective Randomized Study |
title_sort | comparison of rifaximin and lactulose for the treatment of hepatic encephalopathy: a prospective randomized study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815818/ https://www.ncbi.nlm.nih.gov/pubmed/15988813 http://dx.doi.org/10.3349/ymj.2005.46.3.399 |
work_keys_str_mv | AT paikyonghan comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT leekwansik comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT hankwanghyub comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT songkunhoon comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT kimmyounghwan comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT moonbyungsoo comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT ahnsanghoon comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT leesejoon comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT parkhyojin comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT leedongki comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT chonchaeyoon comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT leesangin comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy AT moonyoungmyoung comparisonofrifaximinandlactuloseforthetreatmentofhepaticencephalopathyaprospectiverandomizedstudy |