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A Comparison of Clinical Features and Mortality among Methicillin-Resistant and Methicillin-Sensitive Strains of Staphylococcus aureus Endocarditis

Our objective was to assess the clinical factors that would reliably distinguish methicillin-resistant S. aureus (MRSA) from methicillin-susceptible S. aureus (MSSA) endocarditis. A retrospective cohort study of clinical features and mortality in patients with MRSA and MSSA endocarditis between Marc...

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Autores principales: Yoon, Hee Jung, Choi, Jun Yong, Kim, Chang Oh, Kim, June Myung, Song, Young Goo
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815834/
https://www.ncbi.nlm.nih.gov/pubmed/16127774
http://dx.doi.org/10.3349/ymj.2005.46.4.496
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author Yoon, Hee Jung
Choi, Jun Yong
Kim, Chang Oh
Kim, June Myung
Song, Young Goo
author_facet Yoon, Hee Jung
Choi, Jun Yong
Kim, Chang Oh
Kim, June Myung
Song, Young Goo
author_sort Yoon, Hee Jung
collection PubMed
description Our objective was to assess the clinical factors that would reliably distinguish methicillin-resistant S. aureus (MRSA) from methicillin-susceptible S. aureus (MSSA) endocarditis. A retrospective cohort study of clinical features and mortality in patients with MRSA and MSSA endocarditis between March 1986 and March 2004 was performed in a 750-bed, tertiary care teaching hospital. A total of 32 patients (10 MRSA [31.3%] vs 22 MSSA [68.7%]) were evaluated. Their mean age and sex ratio (male/female) were as follows: 30.8 ± 16.0 vs 24.4±19.6 years old and 6/4 vs 13/9, for MRSA and MSSA infective endocarditis (IE), respectively. Univariate and multivariate analyses revealed that persistent bacteremia was significantly more prevalent in MRSA IE (OR, 10.0 [1.480-67.552]; p, 0.018). There was a higher mortality trend for MRSA IE (50.0%) than for MSSA IE (9.1%) (p=0.019). However, persistent bacteremia was not associated with higher mortality (p>0.05). These results indicate that if persistent bacteremia is documented, the likelihood of MRSA endocarditis should be viewed as high, and the patient's antistaphylococcal therapy should be prolonged and/or changed to a more "potent" regimen.
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spelling pubmed-28158342010-02-04 A Comparison of Clinical Features and Mortality among Methicillin-Resistant and Methicillin-Sensitive Strains of Staphylococcus aureus Endocarditis Yoon, Hee Jung Choi, Jun Yong Kim, Chang Oh Kim, June Myung Song, Young Goo Yonsei Med J Original Article Our objective was to assess the clinical factors that would reliably distinguish methicillin-resistant S. aureus (MRSA) from methicillin-susceptible S. aureus (MSSA) endocarditis. A retrospective cohort study of clinical features and mortality in patients with MRSA and MSSA endocarditis between March 1986 and March 2004 was performed in a 750-bed, tertiary care teaching hospital. A total of 32 patients (10 MRSA [31.3%] vs 22 MSSA [68.7%]) were evaluated. Their mean age and sex ratio (male/female) were as follows: 30.8 ± 16.0 vs 24.4±19.6 years old and 6/4 vs 13/9, for MRSA and MSSA infective endocarditis (IE), respectively. Univariate and multivariate analyses revealed that persistent bacteremia was significantly more prevalent in MRSA IE (OR, 10.0 [1.480-67.552]; p, 0.018). There was a higher mortality trend for MRSA IE (50.0%) than for MSSA IE (9.1%) (p=0.019). However, persistent bacteremia was not associated with higher mortality (p>0.05). These results indicate that if persistent bacteremia is documented, the likelihood of MRSA endocarditis should be viewed as high, and the patient's antistaphylococcal therapy should be prolonged and/or changed to a more "potent" regimen. Yonsei University College of Medicine 2005-08-31 2005-08-31 /pmc/articles/PMC2815834/ /pubmed/16127774 http://dx.doi.org/10.3349/ymj.2005.46.4.496 Text en Copyright © 2005 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoon, Hee Jung
Choi, Jun Yong
Kim, Chang Oh
Kim, June Myung
Song, Young Goo
A Comparison of Clinical Features and Mortality among Methicillin-Resistant and Methicillin-Sensitive Strains of Staphylococcus aureus Endocarditis
title A Comparison of Clinical Features and Mortality among Methicillin-Resistant and Methicillin-Sensitive Strains of Staphylococcus aureus Endocarditis
title_full A Comparison of Clinical Features and Mortality among Methicillin-Resistant and Methicillin-Sensitive Strains of Staphylococcus aureus Endocarditis
title_fullStr A Comparison of Clinical Features and Mortality among Methicillin-Resistant and Methicillin-Sensitive Strains of Staphylococcus aureus Endocarditis
title_full_unstemmed A Comparison of Clinical Features and Mortality among Methicillin-Resistant and Methicillin-Sensitive Strains of Staphylococcus aureus Endocarditis
title_short A Comparison of Clinical Features and Mortality among Methicillin-Resistant and Methicillin-Sensitive Strains of Staphylococcus aureus Endocarditis
title_sort comparison of clinical features and mortality among methicillin-resistant and methicillin-sensitive strains of staphylococcus aureus endocarditis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815834/
https://www.ncbi.nlm.nih.gov/pubmed/16127774
http://dx.doi.org/10.3349/ymj.2005.46.4.496
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