Cargando…

A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats

In women facing menopause, end of menstrual activity is accompanied by lower levels of estrogen and gradual weight gain. Postmenopausal weight gain sounds an alarm for women's health and may lead to hyperlipidemia, a lipid increase and glucose intolerance. These phenomena are connected to lifes...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamakawa, Jun-ichi, Moriya, Junji, Takahashi, Takashi, Ishige, Atsushi, Motoo, Yoshiharu, Yoshizaki, Fumihiko, Kanda, Tsugiyasu
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816381/
https://www.ncbi.nlm.nih.gov/pubmed/18955282
http://dx.doi.org/10.1093/ecam/nem153
_version_ 1782177106428428288
author Yamakawa, Jun-ichi
Moriya, Junji
Takahashi, Takashi
Ishige, Atsushi
Motoo, Yoshiharu
Yoshizaki, Fumihiko
Kanda, Tsugiyasu
author_facet Yamakawa, Jun-ichi
Moriya, Junji
Takahashi, Takashi
Ishige, Atsushi
Motoo, Yoshiharu
Yoshizaki, Fumihiko
Kanda, Tsugiyasu
author_sort Yamakawa, Jun-ichi
collection PubMed
description In women facing menopause, end of menstrual activity is accompanied by lower levels of estrogen and gradual weight gain. Postmenopausal weight gain sounds an alarm for women's health and may lead to hyperlipidemia, a lipid increase and glucose intolerance. These phenomena are connected to lifestyle-related diseases such as hypertension, type II diabetes mellitus, arteriosclerosis and metabolic syndrome, making it essential to prevent weight gain in women. A Kampo medicine, Boi-ogi-to, is traditionally used to treat obese conditions, but the mechanism has not yet been investigated. In this experiment, we tested the antiobesity properties of Boi-ogi-to in ovariectomized rats by measuring changes of serum cytokine levels and adipocytokines in fat cells. After treatment with this extract for 6 weeks (20-week-old rats), we found that there was a significant weight decrease in rats treated with Boi-ogi-to as compared with that in the control group. Serum tumor necrosis factor (TNF)-α levels increased significantly in a dose-dependent manner. Gene expression of adipose tissue in uterus also dose dependently showed a significant increase of TNF-α levels, suggesting that secretion of TNF-α by fat cells might play a role in the ability of Boi-ogi-to to inhibit weight gain. While peroxisome proliferators-activated receptor-γ and adiponectin levels did not show a significant difference as compared with those in the control, levels of mRNA expression showed a tendency to increase dose dependently. Resistin did not show any significant change. These results suggest that Boi-ogi-to might be useful for the prevention of obesity that occurs in women with reduction of estrogen.
format Text
id pubmed-2816381
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-28163812011-03-01 A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats Yamakawa, Jun-ichi Moriya, Junji Takahashi, Takashi Ishige, Atsushi Motoo, Yoshiharu Yoshizaki, Fumihiko Kanda, Tsugiyasu Evid Based Complement Alternat Med Original Articles - Basic Science In women facing menopause, end of menstrual activity is accompanied by lower levels of estrogen and gradual weight gain. Postmenopausal weight gain sounds an alarm for women's health and may lead to hyperlipidemia, a lipid increase and glucose intolerance. These phenomena are connected to lifestyle-related diseases such as hypertension, type II diabetes mellitus, arteriosclerosis and metabolic syndrome, making it essential to prevent weight gain in women. A Kampo medicine, Boi-ogi-to, is traditionally used to treat obese conditions, but the mechanism has not yet been investigated. In this experiment, we tested the antiobesity properties of Boi-ogi-to in ovariectomized rats by measuring changes of serum cytokine levels and adipocytokines in fat cells. After treatment with this extract for 6 weeks (20-week-old rats), we found that there was a significant weight decrease in rats treated with Boi-ogi-to as compared with that in the control group. Serum tumor necrosis factor (TNF)-α levels increased significantly in a dose-dependent manner. Gene expression of adipose tissue in uterus also dose dependently showed a significant increase of TNF-α levels, suggesting that secretion of TNF-α by fat cells might play a role in the ability of Boi-ogi-to to inhibit weight gain. While peroxisome proliferators-activated receptor-γ and adiponectin levels did not show a significant difference as compared with those in the control, levels of mRNA expression showed a tendency to increase dose dependently. Resistin did not show any significant change. These results suggest that Boi-ogi-to might be useful for the prevention of obesity that occurs in women with reduction of estrogen. Oxford University Press 2010-03 2007-11-14 /pmc/articles/PMC2816381/ /pubmed/18955282 http://dx.doi.org/10.1093/ecam/nem153 Text en © 2007 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles - Basic Science
Yamakawa, Jun-ichi
Moriya, Junji
Takahashi, Takashi
Ishige, Atsushi
Motoo, Yoshiharu
Yoshizaki, Fumihiko
Kanda, Tsugiyasu
A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats
title A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats
title_full A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats
title_fullStr A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats
title_full_unstemmed A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats
title_short A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats
title_sort kampo medicine, boi-ogi-to, inhibits obesity in ovariectomized rats
topic Original Articles - Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816381/
https://www.ncbi.nlm.nih.gov/pubmed/18955282
http://dx.doi.org/10.1093/ecam/nem153
work_keys_str_mv AT yamakawajunichi akampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT moriyajunji akampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT takahashitakashi akampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT ishigeatsushi akampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT motooyoshiharu akampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT yoshizakifumihiko akampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT kandatsugiyasu akampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT yamakawajunichi kampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT moriyajunji kampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT takahashitakashi kampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT ishigeatsushi kampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT motooyoshiharu kampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT yoshizakifumihiko kampomedicineboiogitoinhibitsobesityinovariectomizedrats
AT kandatsugiyasu kampomedicineboiogitoinhibitsobesityinovariectomizedrats