Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats

We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Ru...

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Autores principales: Vinogradova, Irina A., Anisimov, Vladimir N., Bukalev, Andrey V., Semenchenko, Anna V., Zabezhinski, Mark A.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816394/
https://www.ncbi.nlm.nih.gov/pubmed/20157558
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author Vinogradova, Irina A.
Anisimov, Vladimir N.
Bukalev, Andrey V.
Semenchenko, Anna V.
Zabezhinski, Mark A.
author_facet Vinogradova, Irina A.
Anisimov, Vladimir N.
Bukalev, Andrey V.
Semenchenko, Anna V.
Zabezhinski, Mark A.
author_sort Vinogradova, Irina A.
collection PubMed
description We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Russia (NL); constant light (LL), and constant darkness (DD) since the age of 25 days until natural death. We found that exposure to NL and LL regimens accelerated development of metabolic syndrome and spontaneous tumorigenesis, shortened life span both in male and females rats as compared to the standard LD regimen. We conclude that circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats. This observation supports the conclusion of the International Agency Research on Cancer that shift-work that involves circadian disruption is probably carcinogenic to humans.
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spelling pubmed-28163942010-02-12 Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats Vinogradova, Irina A. Anisimov, Vladimir N. Bukalev, Andrey V. Semenchenko, Anna V. Zabezhinski, Mark A. Aging (Albany NY) Research Article We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Russia (NL); constant light (LL), and constant darkness (DD) since the age of 25 days until natural death. We found that exposure to NL and LL regimens accelerated development of metabolic syndrome and spontaneous tumorigenesis, shortened life span both in male and females rats as compared to the standard LD regimen. We conclude that circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats. This observation supports the conclusion of the International Agency Research on Cancer that shift-work that involves circadian disruption is probably carcinogenic to humans. Impact Journals LLC 2009-10-02 /pmc/articles/PMC2816394/ /pubmed/20157558 Text en Copyright: ©2009 Vinogradova et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vinogradova, Irina A.
Anisimov, Vladimir N.
Bukalev, Andrey V.
Semenchenko, Anna V.
Zabezhinski, Mark A.
Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
title Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
title_full Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
title_fullStr Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
title_full_unstemmed Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
title_short Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
title_sort circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816394/
https://www.ncbi.nlm.nih.gov/pubmed/20157558
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