COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

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It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodolo...

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Autores principales: Tomlinson, I P M, Dunlop, M, Campbell, H, Zanke, B, Gallinger, S, Hudson, T, Koessler, T, Pharoah, P D, Niittymäkix, I, Tuupanenx, S, Aaltonen, L A, Hemminki, K, Lindblom, A, Försti, A, Sieber, O, Lipton, L, van Wezel, T, Morreau, H, Wijnen, J T, Devilee, P, Matsuda, K, Nakamura, Y, Castellví-Bel, S, Ruiz-Ponte, C, Castells, A, Carracedo, A, Ho, J W C, Sham, P, Hofstra, R M W, Vodicka, P, Brenner, H, Hampe, J, Schafmayer, C, Tepel, J, Schreiber, S, Völzke, H, Lerch, M M, Schmidt, C A, Buch, S, Moreno, V, Villanueva, C M, Peterlongo, P, Radice, P, Echeverry, M M, Velez, A, Carvajal-Carmona, L, Scott, R, Penegar, S, Broderick, P, Tenesa, A, Houlston, R S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816642/
https://www.ncbi.nlm.nih.gov/pubmed/19920828
http://dx.doi.org/10.1038/sj.bjc.6605338
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author Tomlinson, I P M
Dunlop, M
Campbell, H
Zanke, B
Gallinger, S
Hudson, T
Koessler, T
Pharoah, P D
Niittymäkix, I
Tuupanenx, S
Aaltonen, L A
Hemminki, K
Lindblom, A
Försti, A
Sieber, O
Lipton, L
van Wezel, T
Morreau, H
Wijnen, J T
Devilee, P
Matsuda, K
Nakamura, Y
Castellví-Bel, S
Ruiz-Ponte, C
Castells, A
Carracedo, A
Ho, J W C
Sham, P
Hofstra, R M W
Vodicka, P
Brenner, H
Hampe, J
Schafmayer, C
Tepel, J
Schreiber, S
Völzke, H
Lerch, M M
Schmidt, C A
Buch, S
Moreno, V
Villanueva, C M
Peterlongo, P
Radice, P
Echeverry, M M
Velez, A
Carvajal-Carmona, L
Scott, R
Penegar, S
Broderick, P
Tenesa, A
Houlston, R S
author_facet Tomlinson, I P M
Dunlop, M
Campbell, H
Zanke, B
Gallinger, S
Hudson, T
Koessler, T
Pharoah, P D
Niittymäkix, I
Tuupanenx, S
Aaltonen, L A
Hemminki, K
Lindblom, A
Försti, A
Sieber, O
Lipton, L
van Wezel, T
Morreau, H
Wijnen, J T
Devilee, P
Matsuda, K
Nakamura, Y
Castellví-Bel, S
Ruiz-Ponte, C
Castells, A
Carracedo, A
Ho, J W C
Sham, P
Hofstra, R M W
Vodicka, P
Brenner, H
Hampe, J
Schafmayer, C
Tepel, J
Schreiber, S
Völzke, H
Lerch, M M
Schmidt, C A
Buch, S
Moreno, V
Villanueva, C M
Peterlongo, P
Radice, P
Echeverry, M M
Velez, A
Carvajal-Carmona, L
Scott, R
Penegar, S
Broderick, P
Tenesa, A
Houlston, R S
author_sort Tomlinson, I P M
collection PubMed
description It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
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spelling pubmed-28166422011-01-19 COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer Tomlinson, I P M Dunlop, M Campbell, H Zanke, B Gallinger, S Hudson, T Koessler, T Pharoah, P D Niittymäkix, I Tuupanenx, S Aaltonen, L A Hemminki, K Lindblom, A Försti, A Sieber, O Lipton, L van Wezel, T Morreau, H Wijnen, J T Devilee, P Matsuda, K Nakamura, Y Castellví-Bel, S Ruiz-Ponte, C Castells, A Carracedo, A Ho, J W C Sham, P Hofstra, R M W Vodicka, P Brenner, H Hampe, J Schafmayer, C Tepel, J Schreiber, S Völzke, H Lerch, M M Schmidt, C A Buch, S Moreno, V Villanueva, C M Peterlongo, P Radice, P Echeverry, M M Velez, A Carvajal-Carmona, L Scott, R Penegar, S Broderick, P Tenesa, A Houlston, R S Br J Cancer Genetics and Genomics It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT. Nature Publishing Group 2010-01-19 2009-11-17 /pmc/articles/PMC2816642/ /pubmed/19920828 http://dx.doi.org/10.1038/sj.bjc.6605338 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Tomlinson, I P M
Dunlop, M
Campbell, H
Zanke, B
Gallinger, S
Hudson, T
Koessler, T
Pharoah, P D
Niittymäkix, I
Tuupanenx, S
Aaltonen, L A
Hemminki, K
Lindblom, A
Försti, A
Sieber, O
Lipton, L
van Wezel, T
Morreau, H
Wijnen, J T
Devilee, P
Matsuda, K
Nakamura, Y
Castellví-Bel, S
Ruiz-Ponte, C
Castells, A
Carracedo, A
Ho, J W C
Sham, P
Hofstra, R M W
Vodicka, P
Brenner, H
Hampe, J
Schafmayer, C
Tepel, J
Schreiber, S
Völzke, H
Lerch, M M
Schmidt, C A
Buch, S
Moreno, V
Villanueva, C M
Peterlongo, P
Radice, P
Echeverry, M M
Velez, A
Carvajal-Carmona, L
Scott, R
Penegar, S
Broderick, P
Tenesa, A
Houlston, R S
COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
title COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
title_full COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
title_fullStr COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
title_full_unstemmed COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
title_short COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
title_sort cogent (colorectal cancer genetics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816642/
https://www.ncbi.nlm.nih.gov/pubmed/19920828
http://dx.doi.org/10.1038/sj.bjc.6605338
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