Cisplatin-induced expression of Gb3 enables verotoxin-1 treatment of cisplatin resistance in malignant pleural mesothelioma cells

BACKGROUND: A major problem with cisplatin treatment is the development of acquired-drug resistance of the tumour cells. Verotoxin-1 (VT-1) exerts its cytotoxicity by targeting the membrane glycolipid globotriasosylceramide (Gb3), a molecule associated with drug resistance. Cisplatin- and VT-1-induc...

Descripción completa

Detalles Bibliográficos
Autores principales: Johansson, D, Andersson, C, Moharer, J, Johansson, A, Behnam-Motlagh, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816648/
https://www.ncbi.nlm.nih.gov/pubmed/20010943
http://dx.doi.org/10.1038/sj.bjc.6605467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816648/
https://www.ncbi.nlm.nih.gov/pubmed/20010943
http://dx.doi.org/10.1038/sj.bjc.6605467

Ejemplares similares