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Inverse tuning of metal binding affinity and protein stability by altering charged coordination residues in designed calcium binding proteins
Ca(2+ )binding proteins are essential for regulating the role of Ca(2+ )in cell signaling and maintaining Ca(2+ )homeostasis. Negatively charged residues such as Asp and Glu are often found in Ca(2+ )binding proteins and are known to influence Ca(2+ )binding affinity and protein stability. In this p...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816670/ https://www.ncbi.nlm.nih.gov/pubmed/20025729 http://dx.doi.org/10.1186/1757-5036-2-11 |