Regulation of Gene Expression in Hepatic Cells by the Mammalian Target of Rapamycin (mTOR)

BACKGROUND: We investigated mTOR regulation of gene expression by studying rapamycin effect in two hepatic cell lines, the non-tumorigenic WB-F344 cells and the tumorigenic WB311 cells. The latter are resistant to the growth inhibitory effects of rapamycin, thus providing us with an opportunity to s...

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Detalles Bibliográficos
Autores principales: Jimenez, Rosa H., Lee, Ju-Seog, Francesconi, Mirko, Castellani, Gastone, Neretti, Nicola, Sanders, Jennifer A., Sedivy, John, Gruppuso, Philip A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816708/
https://www.ncbi.nlm.nih.gov/pubmed/20140209
http://dx.doi.org/10.1371/journal.pone.0009084

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