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Amino Acid Insertion Reveals a Necessary Three-Helical Intermediate in the Folding Pathway of the Colicin E7 Immunity Protein Im7

The small (87-residue) α-helical protein Im7 (an inhibitor protein for colicin E7 that provides immunity to cells producing colicin E7) folds via a three-state mechanism involving an on-pathway intermediate. This kinetic intermediate contains three of four native helices that are oriented in a non-n...

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Detalles Bibliográficos
Autores principales:	Knowling, Stuart E., Figueiredo, Angelo Miguel, Whittaker, Sara B.-M., Moore, Geoffrey R., Radford, Sheena E.
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816726/ https://www.ncbi.nlm.nih.gov/pubmed/19651139 http://dx.doi.org/10.1016/j.jmb.2009.07.085

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