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Plasmodium berghei crystalloids contain multiple LCCL proteins

Malaria crystalloids are unique organelles of unknown function that are present only in the mosquito-specific ookinete and early oocyst stages of the parasite. Recently, crystalloid formation in Plasmodium berghei was linked to the parasite protein PbSR, a member of the Plasmodium LCCL protein famil...

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Detalles Bibliográficos
Autores principales: Saeed, Sadia, Carter, Victoria, Tremp, Annie Z., Dessens, Johannes T.
Formato: Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816727/
https://www.ncbi.nlm.nih.gov/pubmed/19932717
http://dx.doi.org/10.1016/j.molbiopara.2009.11.008
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author Saeed, Sadia
Carter, Victoria
Tremp, Annie Z.
Dessens, Johannes T.
author_facet Saeed, Sadia
Carter, Victoria
Tremp, Annie Z.
Dessens, Johannes T.
author_sort Saeed, Sadia
collection PubMed
description Malaria crystalloids are unique organelles of unknown function that are present only in the mosquito-specific ookinete and early oocyst stages of the parasite. Recently, crystalloid formation in Plasmodium berghei was linked to the parasite protein PbSR, a member of the Plasmodium LCCL protein family composed of six modular multidomain proteins involved in sporozoite development and infectivity. Here, we show by fluorescent protein tagging that two other LCCL protein family members are targeted to the crystalloids in a similar way to PbSR. These results extend the similarities between the LCCL proteins, and provide strong supporting evidence for the hypothesis that members of this protein family work in concert and are involved in a similar molecular process.
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spelling pubmed-28167272010-02-26 Plasmodium berghei crystalloids contain multiple LCCL proteins Saeed, Sadia Carter, Victoria Tremp, Annie Z. Dessens, Johannes T. Mol Biochem Parasitol Short Communication Malaria crystalloids are unique organelles of unknown function that are present only in the mosquito-specific ookinete and early oocyst stages of the parasite. Recently, crystalloid formation in Plasmodium berghei was linked to the parasite protein PbSR, a member of the Plasmodium LCCL protein family composed of six modular multidomain proteins involved in sporozoite development and infectivity. Here, we show by fluorescent protein tagging that two other LCCL protein family members are targeted to the crystalloids in a similar way to PbSR. These results extend the similarities between the LCCL proteins, and provide strong supporting evidence for the hypothesis that members of this protein family work in concert and are involved in a similar molecular process. Elsevier/North-Holland Biomedical Press 2010-03 /pmc/articles/PMC2816727/ /pubmed/19932717 http://dx.doi.org/10.1016/j.molbiopara.2009.11.008 Text en © 2010 Elsevier B.V. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Short Communication
Saeed, Sadia
Carter, Victoria
Tremp, Annie Z.
Dessens, Johannes T.
Plasmodium berghei crystalloids contain multiple LCCL proteins
title Plasmodium berghei crystalloids contain multiple LCCL proteins
title_full Plasmodium berghei crystalloids contain multiple LCCL proteins
title_fullStr Plasmodium berghei crystalloids contain multiple LCCL proteins
title_full_unstemmed Plasmodium berghei crystalloids contain multiple LCCL proteins
title_short Plasmodium berghei crystalloids contain multiple LCCL proteins
title_sort plasmodium berghei crystalloids contain multiple lccl proteins
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816727/
https://www.ncbi.nlm.nih.gov/pubmed/19932717
http://dx.doi.org/10.1016/j.molbiopara.2009.11.008
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