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Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes

Developed countries are suffering from an epidemic rise in immunologic disorders, such as allergy-related diseases and certain autoimmunities. Several studies have demonstrated a negative association between helminth infections and inflammatory diseases (eg, allergy), providing a strong case for the...

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Autores principales: Smits, Hermelijn H., Everts, Bart, Hartgers, Franca C., Yazdanbakhsh, Maria
Formato: Texto
Lenguaje:English
Publicado: Current Science Inc. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816799/
https://www.ncbi.nlm.nih.gov/pubmed/20425508
http://dx.doi.org/10.1007/s11882-009-0085-3
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author Smits, Hermelijn H.
Everts, Bart
Hartgers, Franca C.
Yazdanbakhsh, Maria
author_facet Smits, Hermelijn H.
Everts, Bart
Hartgers, Franca C.
Yazdanbakhsh, Maria
author_sort Smits, Hermelijn H.
collection PubMed
description Developed countries are suffering from an epidemic rise in immunologic disorders, such as allergy-related diseases and certain autoimmunities. Several studies have demonstrated a negative association between helminth infections and inflammatory diseases (eg, allergy), providing a strong case for the involvement of helminth infections in this respect. However, some studies point in the opposite direction. The discrepancy may be explained by differences in frequency, dose, time, and type of helminth. In this review, new studies are discussed that may support the concept that chronic helminth infections in particular—but not acute infections—are associated with the expression of regulatory networks necessary for downmodulating allergic immune responses to harmless antigens. Furthermore, different components of regulatory networks are highlighted, such as the role of regulatory T and B cells, modulation of dendritic cells, early innate signals from structural cells (eg, epithelial cells), and their individual contributions to protection against allergic diseases. It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations.
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spelling pubmed-28167992010-02-13 Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes Smits, Hermelijn H. Everts, Bart Hartgers, Franca C. Yazdanbakhsh, Maria Curr Allergy Asthma Rep Article Developed countries are suffering from an epidemic rise in immunologic disorders, such as allergy-related diseases and certain autoimmunities. Several studies have demonstrated a negative association between helminth infections and inflammatory diseases (eg, allergy), providing a strong case for the involvement of helminth infections in this respect. However, some studies point in the opposite direction. The discrepancy may be explained by differences in frequency, dose, time, and type of helminth. In this review, new studies are discussed that may support the concept that chronic helminth infections in particular—but not acute infections—are associated with the expression of regulatory networks necessary for downmodulating allergic immune responses to harmless antigens. Furthermore, different components of regulatory networks are highlighted, such as the role of regulatory T and B cells, modulation of dendritic cells, early innate signals from structural cells (eg, epithelial cells), and their individual contributions to protection against allergic diseases. It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations. Current Science Inc. 2010-01-06 2010 /pmc/articles/PMC2816799/ /pubmed/20425508 http://dx.doi.org/10.1007/s11882-009-0085-3 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Smits, Hermelijn H.
Everts, Bart
Hartgers, Franca C.
Yazdanbakhsh, Maria
Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes
title Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes
title_full Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes
title_fullStr Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes
title_full_unstemmed Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes
title_short Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes
title_sort chronic helminth infections protect against allergic diseases by active regulatory processes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816799/
https://www.ncbi.nlm.nih.gov/pubmed/20425508
http://dx.doi.org/10.1007/s11882-009-0085-3
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