Expression Pattern of Immunoproteasome Subunits in Human Thymus

The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subu...

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Detalles Bibliográficos
Autores principales: Oh, Kwon Ik, Seo, Jae Nam
Formato: Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2009
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816962/
https://www.ncbi.nlm.nih.gov/pubmed/20157616
http://dx.doi.org/10.4110/in.2009.9.6.285
Descripción
Sumario:The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.

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