Expression Pattern of Immunoproteasome Subunits in Human Thymus

The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subu...

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Detalles Bibliográficos
Autores principales: Oh, Kwon Ik, Seo, Jae Nam
Formato: Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2009
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816962/
https://www.ncbi.nlm.nih.gov/pubmed/20157616
http://dx.doi.org/10.4110/in.2009.9.6.285
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author Oh, Kwon Ik
Seo, Jae Nam
author_facet Oh, Kwon Ik
Seo, Jae Nam
author_sort Oh, Kwon Ik
collection PubMed
description The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.
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spelling pubmed-28169622010-02-12 Expression Pattern of Immunoproteasome Subunits in Human Thymus Oh, Kwon Ik Seo, Jae Nam Immune Netw Brief Communication The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes. The Korean Association of Immunologists 2009-12 2009-12-31 /pmc/articles/PMC2816962/ /pubmed/20157616 http://dx.doi.org/10.4110/in.2009.9.6.285 Text en Copyright © 2009 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Oh, Kwon Ik
Seo, Jae Nam
Expression Pattern of Immunoproteasome Subunits in Human Thymus
title Expression Pattern of Immunoproteasome Subunits in Human Thymus
title_full Expression Pattern of Immunoproteasome Subunits in Human Thymus
title_fullStr Expression Pattern of Immunoproteasome Subunits in Human Thymus
title_full_unstemmed Expression Pattern of Immunoproteasome Subunits in Human Thymus
title_short Expression Pattern of Immunoproteasome Subunits in Human Thymus
title_sort expression pattern of immunoproteasome subunits in human thymus
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816962/
https://www.ncbi.nlm.nih.gov/pubmed/20157616
http://dx.doi.org/10.4110/in.2009.9.6.285
work_keys_str_mv AT ohkwonik expressionpatternofimmunoproteasomesubunitsinhumanthymus
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