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Outcomes in a diabetic population of south Asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study

BACKGROUND: The aim of this study was to determine whether South Asian patients with diabetes have a worse prognosis following hospitalization for acute myocardial infarction (AMI) compared with their White counterparts. We measured the risk of developing a composite cardiovascular outcome of recurr...

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Autores principales: Nijjar, Aman PK, Wang, Hong, Dasgupta, Kaberi, Rabi, Doreen M, Quan, Hude, Khan, Nadia A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816974/
https://www.ncbi.nlm.nih.gov/pubmed/20096107
http://dx.doi.org/10.1186/1475-2840-9-4
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author Nijjar, Aman PK
Wang, Hong
Dasgupta, Kaberi
Rabi, Doreen M
Quan, Hude
Khan, Nadia A
author_facet Nijjar, Aman PK
Wang, Hong
Dasgupta, Kaberi
Rabi, Doreen M
Quan, Hude
Khan, Nadia A
author_sort Nijjar, Aman PK
collection PubMed
description BACKGROUND: The aim of this study was to determine whether South Asian patients with diabetes have a worse prognosis following hospitalization for acute myocardial infarction (AMI) compared with their White counterparts. We measured the risk of developing a composite cardiovascular outcome of recurrent AMI, congestive heart failure (CHF) requiring hospitalization, or death, in these two groups. METHODS: Using hospital administrative data, we performed a retrospective cohort study of 41,615 patients with an incident AMI in British Columbia and the Calgary Health Region between April 1, 1995, and March 31, 2002. South Asian ethnicity was determined using validated surname analysis. Baseline demographic characteristics and co-morbidities were included in Cox proportional hazard models to compare time to reaching the composite outcome and its individual components. RESULTS: Among the AMI cohort, 29.7% of South Asian patients and 17.6% of White patients were identified as having diabetes (n = 7416). There was no significant difference in risk of developing the composite cardiovascular outcome (Hazard Ratio = 0.90, 95% CI = 0.80-1.01). However, South Asian patients had significantly lower mortality at long term follow-up (HR = 0.62, 95% CI = 0.51-0.74) compared to their White counterparts. CONCLUSIONS: Following hospitalization for AMI, South Asian patients with diabetes do not have a significantly different long term risk of a composite cardiovascular outcome compared to White patients with diabetes. While previous research has suggested worse cardiovascular outcomes in the South Asian population, we found lower long-term mortality among South Asians with diabetes following AMI.
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spelling pubmed-28169742010-02-07 Outcomes in a diabetic population of south Asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study Nijjar, Aman PK Wang, Hong Dasgupta, Kaberi Rabi, Doreen M Quan, Hude Khan, Nadia A Cardiovasc Diabetol Original investigation BACKGROUND: The aim of this study was to determine whether South Asian patients with diabetes have a worse prognosis following hospitalization for acute myocardial infarction (AMI) compared with their White counterparts. We measured the risk of developing a composite cardiovascular outcome of recurrent AMI, congestive heart failure (CHF) requiring hospitalization, or death, in these two groups. METHODS: Using hospital administrative data, we performed a retrospective cohort study of 41,615 patients with an incident AMI in British Columbia and the Calgary Health Region between April 1, 1995, and March 31, 2002. South Asian ethnicity was determined using validated surname analysis. Baseline demographic characteristics and co-morbidities were included in Cox proportional hazard models to compare time to reaching the composite outcome and its individual components. RESULTS: Among the AMI cohort, 29.7% of South Asian patients and 17.6% of White patients were identified as having diabetes (n = 7416). There was no significant difference in risk of developing the composite cardiovascular outcome (Hazard Ratio = 0.90, 95% CI = 0.80-1.01). However, South Asian patients had significantly lower mortality at long term follow-up (HR = 0.62, 95% CI = 0.51-0.74) compared to their White counterparts. CONCLUSIONS: Following hospitalization for AMI, South Asian patients with diabetes do not have a significantly different long term risk of a composite cardiovascular outcome compared to White patients with diabetes. While previous research has suggested worse cardiovascular outcomes in the South Asian population, we found lower long-term mortality among South Asians with diabetes following AMI. BioMed Central 2010-01-22 /pmc/articles/PMC2816974/ /pubmed/20096107 http://dx.doi.org/10.1186/1475-2840-9-4 Text en Copyright ©2010 Nijjar et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original investigation
Nijjar, Aman PK
Wang, Hong
Dasgupta, Kaberi
Rabi, Doreen M
Quan, Hude
Khan, Nadia A
Outcomes in a diabetic population of south Asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study
title Outcomes in a diabetic population of south Asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study
title_full Outcomes in a diabetic population of south Asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study
title_fullStr Outcomes in a diabetic population of south Asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study
title_full_unstemmed Outcomes in a diabetic population of south Asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study
title_short Outcomes in a diabetic population of south Asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study
title_sort outcomes in a diabetic population of south asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study
topic Original investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816974/
https://www.ncbi.nlm.nih.gov/pubmed/20096107
http://dx.doi.org/10.1186/1475-2840-9-4
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