Unexpected Tolerance of α-Cleavage of the Prion Protein to Sequence Variations

The cellular form of the prion protein, PrP(C), undergoes extensive proteolysis at the α site (109K↓H110). Expression of non-cleavable PrP(C) mutants in transgenic mice correlates with neurotoxicity, suggesting that α-cleavage is important for PrP(C) physiology. To gain insights into the mechanisms...

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Detalles Bibliográficos
Autores principales: Oliveira-Martins, José B., Yusa, Sei-ichi, Calella, Anna Maria, Bridel, Claire, Baumann, Frank, Dametto, Paolo, Aguzzi, Adriano
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817006/
https://www.ncbi.nlm.nih.gov/pubmed/20161712
http://dx.doi.org/10.1371/journal.pone.0009107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817006/
https://www.ncbi.nlm.nih.gov/pubmed/20161712
http://dx.doi.org/10.1371/journal.pone.0009107

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