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Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy

Human papillomavirus (HPV) type-specific distribution was evaluated in genital samples collected from 654 women from the South of Italy undergoing voluntary screening and correlated with cyto-histological abnormalities. HPV DNA was detected in 45.9% of the samples, 41.7% of which had multiple infect...

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Autores principales: Menegazzi, Paola, Barzon, Luisa, Palù, Giorgio, Reho, Elisa, Tagliaferro, Luigi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817385/
https://www.ncbi.nlm.nih.gov/pubmed/20145716
http://dx.doi.org/10.1155/2009/198425
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author Menegazzi, Paola
Barzon, Luisa
Palù, Giorgio
Reho, Elisa
Tagliaferro, Luigi
author_facet Menegazzi, Paola
Barzon, Luisa
Palù, Giorgio
Reho, Elisa
Tagliaferro, Luigi
author_sort Menegazzi, Paola
collection PubMed
description Human papillomavirus (HPV) type-specific distribution was evaluated in genital samples collected from 654 women from the South of Italy undergoing voluntary screening and correlated with cyto-histological abnormalities. HPV DNA was detected in 45.9% of the samples, 41.7% of which had multiple infection and 89.0% had high-risk HPV infection. The prevalence of HPV infection and the rate of multiple infections decreased with age, suggesting natural selection of HPV types with better fitness. In line with other Italian studies, the most common HPV types were HPV-6 and HPV-16, followed by HPV-51, HPV-31, HPV-53, and HPV-66, in women with both normal and abnormal cytology. Cervical intraepithelial lesions grade 2 or 3 were associated with high-risk HPV-16, HPV-18, HPV-31, and HPV-51 infection. These data indicate that prophylactic HPV vaccination is expected to reduce the burden of HPV-related cervical lesions in this population, but also suggest the potential utility of new vaccines with larger type coverage.
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spelling pubmed-28173852010-02-09 Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy Menegazzi, Paola Barzon, Luisa Palù, Giorgio Reho, Elisa Tagliaferro, Luigi Infect Dis Obstet Gynecol Research Article Human papillomavirus (HPV) type-specific distribution was evaluated in genital samples collected from 654 women from the South of Italy undergoing voluntary screening and correlated with cyto-histological abnormalities. HPV DNA was detected in 45.9% of the samples, 41.7% of which had multiple infection and 89.0% had high-risk HPV infection. The prevalence of HPV infection and the rate of multiple infections decreased with age, suggesting natural selection of HPV types with better fitness. In line with other Italian studies, the most common HPV types were HPV-6 and HPV-16, followed by HPV-51, HPV-31, HPV-53, and HPV-66, in women with both normal and abnormal cytology. Cervical intraepithelial lesions grade 2 or 3 were associated with high-risk HPV-16, HPV-18, HPV-31, and HPV-51 infection. These data indicate that prophylactic HPV vaccination is expected to reduce the burden of HPV-related cervical lesions in this population, but also suggest the potential utility of new vaccines with larger type coverage. Hindawi Publishing Corporation 2009 2010-01-24 /pmc/articles/PMC2817385/ /pubmed/20145716 http://dx.doi.org/10.1155/2009/198425 Text en Copyright © 2009 Paola Menegazzi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Menegazzi, Paola
Barzon, Luisa
Palù, Giorgio
Reho, Elisa
Tagliaferro, Luigi
Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy
title Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy
title_full Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy
title_fullStr Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy
title_full_unstemmed Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy
title_short Human Papillomavirus Type Distribution and Correlation with Cyto-Histological Patterns in Women from the South of Italy
title_sort human papillomavirus type distribution and correlation with cyto-histological patterns in women from the south of italy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817385/
https://www.ncbi.nlm.nih.gov/pubmed/20145716
http://dx.doi.org/10.1155/2009/198425
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