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Independent Mammalian Genome Contractions Following the KT Boundary

Although it is generally accepted that major changes in the earth's history are significant drivers of phylogenetic diversification and extinction, such episodes may also have long-lasting effects on genomic architecture. Here we show that widespread reductions in genome size have occurred in m...

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Detalles Bibliográficos
Autores principales: Rho, Mina, Zhou, Mo, Gao, Xiang, Kim, Sun, Tang, Haixu, Lynch, Michael
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817402/
https://www.ncbi.nlm.nih.gov/pubmed/20333172
http://dx.doi.org/10.1093/gbe/evp007
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author Rho, Mina
Zhou, Mo
Gao, Xiang
Kim, Sun
Tang, Haixu
Lynch, Michael
author_facet Rho, Mina
Zhou, Mo
Gao, Xiang
Kim, Sun
Tang, Haixu
Lynch, Michael
author_sort Rho, Mina
collection PubMed
description Although it is generally accepted that major changes in the earth's history are significant drivers of phylogenetic diversification and extinction, such episodes may also have long-lasting effects on genomic architecture. Here we show that widespread reductions in genome size have occurred in multiple lineages of mammals subsequent to the Cretaceous–Tertiary (KT) boundary, whereas there is no evidence for such changes in other vertebrate, invertebrate, or land plant lineages. Although the mechanisms remain unclear, such shifts in mammalian genome evolution may be a consequence of an increase in the efficiency of selection against excess DNA resulting from post-KT population size expansions. Independent historical changes in genome architecture in diverse lineages raise a significant challenge to the idea that genome size is finely tuned to achieve adaptive phenotypic modifications and suggest that attempts to use phylogenetic analysis to infer ancestral genome sizes may be problematical.
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spelling pubmed-28174022010-03-22 Independent Mammalian Genome Contractions Following the KT Boundary Rho, Mina Zhou, Mo Gao, Xiang Kim, Sun Tang, Haixu Lynch, Michael Genome Biol Evol Research Articles Although it is generally accepted that major changes in the earth's history are significant drivers of phylogenetic diversification and extinction, such episodes may also have long-lasting effects on genomic architecture. Here we show that widespread reductions in genome size have occurred in multiple lineages of mammals subsequent to the Cretaceous–Tertiary (KT) boundary, whereas there is no evidence for such changes in other vertebrate, invertebrate, or land plant lineages. Although the mechanisms remain unclear, such shifts in mammalian genome evolution may be a consequence of an increase in the efficiency of selection against excess DNA resulting from post-KT population size expansions. Independent historical changes in genome architecture in diverse lineages raise a significant challenge to the idea that genome size is finely tuned to achieve adaptive phenotypic modifications and suggest that attempts to use phylogenetic analysis to infer ancestral genome sizes may be problematical. Oxford University Press 2009 2009-05-05 /pmc/articles/PMC2817402/ /pubmed/20333172 http://dx.doi.org/10.1093/gbe/evp007 Text en © The Author(s) 2009. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Rho, Mina
Zhou, Mo
Gao, Xiang
Kim, Sun
Tang, Haixu
Lynch, Michael
Independent Mammalian Genome Contractions Following the KT Boundary
title Independent Mammalian Genome Contractions Following the KT Boundary
title_full Independent Mammalian Genome Contractions Following the KT Boundary
title_fullStr Independent Mammalian Genome Contractions Following the KT Boundary
title_full_unstemmed Independent Mammalian Genome Contractions Following the KT Boundary
title_short Independent Mammalian Genome Contractions Following the KT Boundary
title_sort independent mammalian genome contractions following the kt boundary
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817402/
https://www.ncbi.nlm.nih.gov/pubmed/20333172
http://dx.doi.org/10.1093/gbe/evp007
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