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SIRT1 deacetylates APE1 and regulates cellular base excision repair
Apurinic/apyrimidinic endonuclease-1 (APE1) is an essential enzyme in the base excision repair (BER) pathway. Here, we show that APE1 is a target of the SIRTUIN1 (SIRT1) protein deacetylase. SIRT1 associates with APE1, and this association is increased with genotoxic stress. SIRT1 deacetylates APE1...
Autores principales: | Yamamori, Tohru, DeRicco, Jeremy, Naqvi, Asma, Hoffman, Timothy A., Mattagajasingh, Ilwola, Kasuno, Kenji, Jung, Saet-Byel, Kim, Cuk-Seong, Irani, Kaikobad |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817463/ https://www.ncbi.nlm.nih.gov/pubmed/19934257 http://dx.doi.org/10.1093/nar/gkp1039 |
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