Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells

Human sirtuin 1 (SIRT1) is a NAD(+)-dependent deacetylase that participates in cell death/survival, senescence and metabolism. Although its substrates are well characterized, no direct regulators have been defined. Here, we show that SIRT1 associates with SKI-interacting protein (SKIP) and modulates...

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Detalles Bibliográficos
Autores principales: Kang, Moo-Rim, Lee, Sang-Wang, Um, Elisa, Kang, Hyun Tae, Hwang, Eun Seong, Kim, Eun-Joo, Um, Soo-Jong
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817470/
https://www.ncbi.nlm.nih.gov/pubmed/19934264
http://dx.doi.org/10.1093/nar/gkp1056

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