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Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota
The daunting task required of the gut-barrier to prevent luminal pathogens and harmful substances from entering into the internal milieu and yet promoting digestion and absorption of nutrients requires an exquisite degree of coordination between the different architectural units of this barrier. The...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817557/ https://www.ncbi.nlm.nih.gov/pubmed/20150966 http://dx.doi.org/10.1155/2010/305879 |
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author | Sharma, Renu Young, Christopher Neu, Josef |
author_facet | Sharma, Renu Young, Christopher Neu, Josef |
author_sort | Sharma, Renu |
collection | PubMed |
description | The daunting task required of the gut-barrier to prevent luminal pathogens and harmful substances from entering into the internal milieu and yet promoting digestion and absorption of nutrients requires an exquisite degree of coordination between the different architectural units of this barrier. The complex integration and execution of these functions are superbly carried out by the intestinal mucosal (IM) surface. Exposed to trillions of luminal microbes, the IM averts threats by signaling to the innate immune system, through pattern recognition receptors (PRR), to respond to the commensal bacteria by developing tolerance (hyporesponsiveness) towards them. This system also acts by protecting against pathogens by elaborating and releasing protective peptides, cytokines, chemokines, and phagocytic cells. The IM is constantly sampling luminal contents and making molecular adjustments at its frontier. This article describes the topography of the IM and the mechanisms of molecular adjustments that protect the internal milieu, and also describes the role of the microbiota in achieving this goal. |
format | Text |
id | pubmed-2817557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28175572010-02-11 Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota Sharma, Renu Young, Christopher Neu, Josef J Biomed Biotechnol Review Article The daunting task required of the gut-barrier to prevent luminal pathogens and harmful substances from entering into the internal milieu and yet promoting digestion and absorption of nutrients requires an exquisite degree of coordination between the different architectural units of this barrier. The complex integration and execution of these functions are superbly carried out by the intestinal mucosal (IM) surface. Exposed to trillions of luminal microbes, the IM averts threats by signaling to the innate immune system, through pattern recognition receptors (PRR), to respond to the commensal bacteria by developing tolerance (hyporesponsiveness) towards them. This system also acts by protecting against pathogens by elaborating and releasing protective peptides, cytokines, chemokines, and phagocytic cells. The IM is constantly sampling luminal contents and making molecular adjustments at its frontier. This article describes the topography of the IM and the mechanisms of molecular adjustments that protect the internal milieu, and also describes the role of the microbiota in achieving this goal. Hindawi Publishing Corporation 2010 2010-01-31 /pmc/articles/PMC2817557/ /pubmed/20150966 http://dx.doi.org/10.1155/2010/305879 Text en Copyright © 2010 Renu Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sharma, Renu Young, Christopher Neu, Josef Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota |
title | Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota |
title_full | Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota |
title_fullStr | Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota |
title_full_unstemmed | Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota |
title_short | Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota |
title_sort | molecular modulation of intestinal epithelial barrier: contribution of microbiota |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817557/ https://www.ncbi.nlm.nih.gov/pubmed/20150966 http://dx.doi.org/10.1155/2010/305879 |
work_keys_str_mv | AT sharmarenu molecularmodulationofintestinalepithelialbarriercontributionofmicrobiota AT youngchristopher molecularmodulationofintestinalepithelialbarriercontributionofmicrobiota AT neujosef molecularmodulationofintestinalepithelialbarriercontributionofmicrobiota |