High Nucleosome Occupancy Is Encoded at Human Regulatory Sequences

Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters, enhancers, and TFBSs generally encodes high i...

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Detalles Bibliográficos
Autores principales: Tillo, Desiree, Kaplan, Noam, Moore, Irene K., Fondufe-Mittendorf, Yvonne, Gossett, Andrea J., Field, Yair, Lieb, Jason D., Widom, Jonathan, Segal, Eran, Hughes, Timothy R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817738/
https://www.ncbi.nlm.nih.gov/pubmed/20161746
http://dx.doi.org/10.1371/journal.pone.0009129

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