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Phenylbutyric Acid Rescues Endoplasmic Reticulum Stress-Induced Suppression of APP Proteolysis and Prevents Apoptosis in Neuronal Cells

BACKGROUND: The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer's disease (FAD) mutations within sporadi...

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Detalles Bibliográficos
Autores principales:	Wiley, Jesse C., Meabon, James S., Frankowski, Harald, Smith, Elise A., Schecterson, Leslayann C., Bothwell, Mark, Ladiges, Warren C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817752/ https://www.ncbi.nlm.nih.gov/pubmed/20161760 http://dx.doi.org/10.1371/journal.pone.0009135

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