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Do mtDNA Mutations Participate in the Pathogenesis of Sporadic Parkinson’s Disease?
The pathogenesis of sporadic Parkinson’s disease (PD) remains enigmatic. Mitochondrial complex-I defects are known to occur in the substantia nigra (SN) of PD patients and are also debated in some extracerebral tissues. Early sequencing efforts of the mitochondrial DNA (mtDNA) did not reveal specifi...
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| Formato: | Texto |
| Lenguaje: | English |
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Bentham Science Publishers Ltd
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817889/ https://www.ncbi.nlm.nih.gov/pubmed/20514220 http://dx.doi.org/10.2174/138920209789503879 |