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No significant effect on bone mineral density by high doses of vitamin D(3 )given to overweight subjects for one year
BACKGROUND: In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high dos...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818614/ https://www.ncbi.nlm.nih.gov/pubmed/20056003 http://dx.doi.org/10.1186/1475-2891-9-1 |
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author | Jorde, Rolf Sneve, Monica Torjesen, Peter A Figenschau, Yngve Hansen, John-Bjarne Grimnes, Guri |
author_facet | Jorde, Rolf Sneve, Monica Torjesen, Peter A Figenschau, Yngve Hansen, John-Bjarne Grimnes, Guri |
author_sort | Jorde, Rolf |
collection | PubMed |
description | BACKGROUND: In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high doses of vitamin D on BMD is more uncertain and could in theory have both positive and negative effects. METHODS: The study was a one year, double blind placebo-controlled intervention trial performed at the University Hospital of North Norway. 421 subjects, 21 - 70 years old, were included and 312 completed the study. The subjects were randomized to vitamin D(3 )40.000 IU per week (DD group), vitamin D(3 )20.000 IU per week (DP group), or placebo (PP group). All subjects were given 500 mg calcium daily. Serum 25(OH)D, osteoprotegrin (OPG), receptoractivator of nuclear factor-kappaB ligand (RANKL), and BMD at the lumbar spine and the hip were measured before and at the end of the study. RESULTS: At baseline the mean serum 25(OH)D levels were 58 nmol/L (all subjects) and increased to 141 and 100 nmol/L in the DD and DP groups, respectively. After one year, no significant differences were found between the three groups regarding change in BMD, serum OPG or RANKL. CONCLUSIONS: Supplementation with high doses of vitamin D for one year does not appear to have a negative effect on BMD in healthy subjects. In order to disclose a positive effect, subjects with low BMD and/or low serum 25(OH)D levels need to be studied. TRIAL REGISTRATION: The trial was registered at ClinicalTrials.gov (NCT00243256). |
format | Text |
id | pubmed-2818614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28186142010-02-10 No significant effect on bone mineral density by high doses of vitamin D(3 )given to overweight subjects for one year Jorde, Rolf Sneve, Monica Torjesen, Peter A Figenschau, Yngve Hansen, John-Bjarne Grimnes, Guri Nutr J Research BACKGROUND: In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high doses of vitamin D on BMD is more uncertain and could in theory have both positive and negative effects. METHODS: The study was a one year, double blind placebo-controlled intervention trial performed at the University Hospital of North Norway. 421 subjects, 21 - 70 years old, were included and 312 completed the study. The subjects were randomized to vitamin D(3 )40.000 IU per week (DD group), vitamin D(3 )20.000 IU per week (DP group), or placebo (PP group). All subjects were given 500 mg calcium daily. Serum 25(OH)D, osteoprotegrin (OPG), receptoractivator of nuclear factor-kappaB ligand (RANKL), and BMD at the lumbar spine and the hip were measured before and at the end of the study. RESULTS: At baseline the mean serum 25(OH)D levels were 58 nmol/L (all subjects) and increased to 141 and 100 nmol/L in the DD and DP groups, respectively. After one year, no significant differences were found between the three groups regarding change in BMD, serum OPG or RANKL. CONCLUSIONS: Supplementation with high doses of vitamin D for one year does not appear to have a negative effect on BMD in healthy subjects. In order to disclose a positive effect, subjects with low BMD and/or low serum 25(OH)D levels need to be studied. TRIAL REGISTRATION: The trial was registered at ClinicalTrials.gov (NCT00243256). BioMed Central 2010-01-07 /pmc/articles/PMC2818614/ /pubmed/20056003 http://dx.doi.org/10.1186/1475-2891-9-1 Text en Copyright ©2010 Jorde et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Jorde, Rolf Sneve, Monica Torjesen, Peter A Figenschau, Yngve Hansen, John-Bjarne Grimnes, Guri No significant effect on bone mineral density by high doses of vitamin D(3 )given to overweight subjects for one year |
title | No significant effect on bone mineral density by high doses of vitamin D(3 )given to overweight subjects for one year |
title_full | No significant effect on bone mineral density by high doses of vitamin D(3 )given to overweight subjects for one year |
title_fullStr | No significant effect on bone mineral density by high doses of vitamin D(3 )given to overweight subjects for one year |
title_full_unstemmed | No significant effect on bone mineral density by high doses of vitamin D(3 )given to overweight subjects for one year |
title_short | No significant effect on bone mineral density by high doses of vitamin D(3 )given to overweight subjects for one year |
title_sort | no significant effect on bone mineral density by high doses of vitamin d(3 )given to overweight subjects for one year |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818614/ https://www.ncbi.nlm.nih.gov/pubmed/20056003 http://dx.doi.org/10.1186/1475-2891-9-1 |
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