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Multiple Native States Reveal Persistent Ruggedness of an RNA Folding Landscape
According to the “thermodynamic hypothesis”, the sequence of a biological macromolecule defines its folded, active structure as a global energy minimum on the folding landscape.1,2 But the enormous complexity of folding landscapes of large macromolecules raises a question: Is there indeed a unique g...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818749/ https://www.ncbi.nlm.nih.gov/pubmed/20130651 http://dx.doi.org/10.1038/nature08717 |