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The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors
During the co-evolution of cytomegalovirus (CMV) and natural killer (NK) cells, each has evolved specific tactics in an attempt to prevail. CMV has evolved multiple immune evasion mechanisms to avoid detection by NK cells and other immune cells, leading to chronic infection. Meanwhile, the host has...
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819288/ https://www.ncbi.nlm.nih.gov/pubmed/20151027 http://dx.doi.org/10.3390/v1030362 |
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author | Sun, Joseph C. Lanier, Lewis L. |
author_facet | Sun, Joseph C. Lanier, Lewis L. |
author_sort | Sun, Joseph C. |
collection | PubMed |
description | During the co-evolution of cytomegalovirus (CMV) and natural killer (NK) cells, each has evolved specific tactics in an attempt to prevail. CMV has evolved multiple immune evasion mechanisms to avoid detection by NK cells and other immune cells, leading to chronic infection. Meanwhile, the host has evolved virus-specific receptors to counter these evasion strategies. The natural selection of viral genes and host receptors allows us to observe a unique molecular example of “survival of the fittest”, as virus and immune cells try to out-maneuver one another or for the virus to achieve détente for optimal dissemination in the population. |
format | Text |
id | pubmed-2819288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-28192882010-02-10 The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors Sun, Joseph C. Lanier, Lewis L. Viruses Review During the co-evolution of cytomegalovirus (CMV) and natural killer (NK) cells, each has evolved specific tactics in an attempt to prevail. CMV has evolved multiple immune evasion mechanisms to avoid detection by NK cells and other immune cells, leading to chronic infection. Meanwhile, the host has evolved virus-specific receptors to counter these evasion strategies. The natural selection of viral genes and host receptors allows us to observe a unique molecular example of “survival of the fittest”, as virus and immune cells try to out-maneuver one another or for the virus to achieve détente for optimal dissemination in the population. Molecular Diversity Preservation International (MDPI) 2009-10-13 /pmc/articles/PMC2819288/ /pubmed/20151027 http://dx.doi.org/10.3390/v1030362 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Sun, Joseph C. Lanier, Lewis L. The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
title | The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
title_full | The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
title_fullStr | The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
title_full_unstemmed | The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
title_short | The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
title_sort | natural selection of herpesviruses and virus-specific nk cell receptors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819288/ https://www.ncbi.nlm.nih.gov/pubmed/20151027 http://dx.doi.org/10.3390/v1030362 |
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